{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:18:38Z","timestamp":1759483118580},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,18]],"date-time":"2001-12-18T00:00:00Z","timestamp":1008633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Animal models have recently clarified the lung injury after allogeneic hematopoietic transplantation. These works have confirmed the role of donor T lymphocytes in immune\u2010mediated inflammatory reactions in the lung. We report here a fatal case of a 3\u2010year\u2010old child who developed acute respiratory failure coinciding with the onset of hyper\u2010acute graft versus host disease (aGVHD) after allogeneic peripheral stem cell transplantation. aGVHD was refractory to treatment and the patient died on day +28. Lung necropsy showed interstitial pneumonia and peribronchial and perivascular infiltration by mononuclear cells, with no viral inclusions. These findings are not specific but have been found by some authors in animal models with acute immune\u2010mediated lung injury related with donor T lymphocytes. Immune\u2010mediated lung injury, as defined by animal models, should be considered in patients with severe signs of systemic aGVHD while excluding other known etiologies of pulmonary disease. Am. J. Hematol. 69:56\u201058, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10040","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T22:17:27Z","timestamp":1030313847000},"page":"56-58","source":"Crossref","is-referenced-by-count":4,"title":["Early onset of acute immune\u2010mediated lung injury in a child undergoing allogeneic peripheral blood transplantation"],"prefix":"10.1002","volume":"69","author":[{"given":"Juli\u00e1n","family":"Sevilla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Gonz\u00e1lez\u2010Vicent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Madero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imelda","family":"Gonz\u00e1lez\u2010Mediero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1056\/NEJM197811092991902","article-title":"Lymphocytic bronchitis associated with graft\u2010versus\u2010host disease in recipients of bone marrow transplants","volume":"299","author":"Beschorner WE","year":"1978","journal-title":"New Engl J Med"},{"key":"e_1_2_1_3_2","first-page":"231","article-title":"An acute pulmonary syndrome possibly representing acute graft\u2010versus\u2010host disease involving the lung interstitium","volume":"8","author":"Atkinson K","year":"1991","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.36.5.546"},{"key":"e_1_2_1_5_2","first-page":"425","volume-title":"Graft\u2010vs\u2010host disease","author":"Madtes DK","year":"1997"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.109.4.1066"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.18.2.2988"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119612"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.7.2571"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(95)90174-4"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.10040","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.10040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T10:51:29Z","timestamp":1700304689000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.10040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12,20]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1002\/ajh.10040"],"URL":"https:\/\/doi.org\/10.1002\/ajh.10040","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12,20]]}}}