{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T19:34:21Z","timestamp":1773084861089,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,2,20]],"date-time":"2002-02-20T00:00:00Z","timestamp":1014163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Common variable immunodeficiency (CVID) is a primary immunodeficiency disease characterized by low serum immunoglobulins IgG, IgA, and usually IgM. The central immune deficiency is impaired secretion of immunoglobulins and lack of antibody production; however, T cell dysfunction and a variety of inflammatory complications suggest global immune dysregulation. A number of reports have documented the association of primary immunodeficiency diseases with the development of non\u2010Hodgkin's lymphoma (NHL). In CVID, the risk has been estimated to lie between 1.4% and 7%. As for NHL arising in other immunodeficiency states, the lymphomas in CVID are extranodal and are usually B cell in type. Of 22 B cell lymphomas that have appeared over a period of 25 years in a cohort of subjects with CVID, five lymphomas, appearing in more recently studied subjects, that arose in mucosal sites would be classified as mucosa\u2010associated lymphoid tissue (MALT) lymphomas. MALT lymphomas are low\u2010grade B cell lymphomas that result from a proliferation of neoplastic marginal\u2010zone related cells of lymphoid tissue and tend to occur in organs that have acquired lymphoid tissue due to long\u2010term infectious or autoimmune stimulation. Lymphomas of this kind have not been described in patients with congenital immunodeficiency, although chronic mucosal antigen stimulation is an integral part of these immune deficiency states. Am. J. Hematol. 69:171\u2013178, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10050","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:10:52Z","timestamp":1030317052000},"page":"171-178","source":"Crossref","is-referenced-by-count":93,"title":["Lymphomas of mucosal\u2010associated lymphoid tissue in common variable immunodeficiency"],"prefix":"10.1002","volume":"69","author":[{"given":"C.","family":"Cunningham\u2010Rundles","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis L.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas P.","family":"Duffy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Strauchen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,2,20]]},"reference":[{"issue":"1","key":"e_1_2_1_2_2","first-page":"1","article-title":"Report of a WHO Scientific Group.","volume":"109","year":"1997","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)01086-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-9-199305010-00011"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/clim.1999.4725"},{"key":"e_1_2_1_6_2","first-page":"31","article-title":"Primary hypogammaglobulinemia: a survey of clinical manifestations and complications.","volume":"86","author":"Hermaszewski RA","year":"1993","journal-title":"Q J Med"},{"key":"e_1_2_1_7_2","first-page":"200","article-title":"Agammaglobulinemia.","volume":"66","author":"Janeway CA","year":"1953","journal-title":"Trans Assoc Am Physicians"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.19.6008"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(90)90145-G"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(92)90234-G"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91940-0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110305"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1994.tb06228.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1997.d01-993.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1992.tb05826.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.3.1099"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00915297"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"5957","DOI":"10.4049\/jimmunol.152.12.5957","article-title":"B cell differentiation defects in common variable immunodeficiency are ameliorated after stimulation with anti\u2010CD40 antibody and IL\u201010.","volume":"152","author":"Eisenstein EM","year":"1994","journal-title":"J Immunol"},{"key":"e_1_2_1_19_2","first-page":"334","article-title":"Peripheral blood lymphocytes of patients with common variable immunodeficiency produce reduced levels of interleukin\u20104, interleukin\u20102 and interferon\u2010gamma, but proliferate normally upon activation with mitogens.","volume":"78","author":"Pastorelli G","year":"1989","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.4049\/jimmunol.144.10.3762","article-title":"Abnormalities of lymphokine gene expression in patients with common variable immunodeficiency.","volume":"144","author":"Sneller MC","year":"1990","journal-title":"J Immunol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(89)90323-X"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(87)90066-3"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2000.01239.x"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-198722000-00017"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198805001-00003"},{"issue":"1","key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/annonc\/11.suppl_1.S141","article-title":"Non\u2010Hodgkin's lymphoma in pediatric patients with chromosomal breakage syndromes (AT and NBS): experience from the BFM trials.","volume":"11","author":"Seidemann K","year":"2000","journal-title":"Ann Oncol"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830370202"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00915550"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840601)53:11<2515::AID-CNCR2820531125>3.0.CO;2-C"},{"key":"e_1_2_1_31_2","first-page":"54","article-title":"Primary gastrointestinal lymphomas.","volume":"4","author":"Cooper DL","year":"1996","journal-title":"Gastroenterologist"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92035-Z"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1999.0443f.x"},{"key":"e_1_2_1_34_2","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1182\/blood.V91.1.360a","article-title":"Chronic hepatitis C virus and gastric MALT lymphoma.","volume":"91","author":"Tkoub EM","year":"1998","journal-title":"Blood"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.d01-1791.x"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80957-5"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-57054-4_16"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200001280-00008"},{"issue":"1","key":"e_1_2_1_39_2","first-page":"21","article-title":"Overview of posttransplant B\u2010cell lymphoproliferative disorders.","volume":"11","author":"Swinnen LJ","year":"1999","journal-title":"Semin Oncol"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199510000-00001"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70456-7"},{"key":"e_1_2_1_42_2","first-page":"979","article-title":"Protein truncation test of LYST reveals heterogeneous mutations in patients with Chediak\u2010Higashi syndrome.","volume":"95","author":"Certain S","year":"2000","journal-title":"Blood"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70123-9"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65742-2"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199212000-00004"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199909058418"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.1.77"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1996.292338.x"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/107.5.592"},{"key":"e_1_2_1_50_2","first-page":"249","article-title":"Primary low grade B\u2010cell lymphoma of the dura in an immunocompetent patient.","volume":"19","author":"Altundag MK","year":"2000","journal-title":"J Exp Clin Cancer Res"},{"key":"e_1_2_1_51_2","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1182\/blood.V95.3.802.003k19_802_806","article-title":"Mucosa\u2010associated lymphoid tissue lymphoma is a disseminated disease in one\u2010third of 158 patients analyzed.","volume":"95","author":"Thieblemont C","year":"2000","journal-title":"Blood"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1999.tb01342.x"},{"key":"e_1_2_1_53_2","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.4049\/jimmunol.161.8.4227","article-title":"The memory B cell subset responsible for the secretory IgA response and protective humoral immunity to rotavirus expresses the intestinal homing receptor, \u03b14\u03b27.","volume":"161","author":"Williams MB","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215549904701210"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199307153290305"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91408-E"},{"key":"e_1_2_1_57_2","first-page":"1353","article-title":"A characterization of tumor\u2010infiltrating T lymphocytes in B\u2010cell lymphomas of mucosal\u2010associated lymphoid tissue.","volume":"151","author":"Koulis A","year":"1997","journal-title":"Am J Pathol"},{"key":"e_1_2_1_58_2","first-page":"1005","article-title":"Fludarabine An update of its pharmacology and use in the treatment of haematological malignancies.","volume":"53","author":"Adkins JC","year":"1997","journal-title":"Rev Drugs"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.10050","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.10050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T11:51:25Z","timestamp":1700221885000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.10050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2,20]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["10.1002\/ajh.10050"],"URL":"https:\/\/doi.org\/10.1002\/ajh.10050","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,2,20]]}}}