{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:45:07Z","timestamp":1761511507627},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,4,30]],"date-time":"2002-04-30T00:00:00Z","timestamp":1020124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two patients, one with B\u2010cell chronic lymphocytic leukemia (CLL) and one with hairy\u2010cell leukemia (HCL), were treated with immunosuppressive chemotherapy. The patient with CLL was a 54\u2010year\u2010old female, who had had a squamous cell carcinoma (SCC) excised from her forehead 5 months before receiving the first course of fludarabine. During the fludarabine treatment, the patient developed a local SCC relapse and metastases in the neck. The carcinoma was treated by excision and radiotherapy, and further fludarabine treatment was withheld. Nevertheless, the SCC metastasized aggressively and the patient died 3 months after the start of fludarabine treatment, primarily due to respiratory failure. The autopsy revealed heavy SCC infiltrations involving the lungs, pleura, mediastinum, pericardium, and liver. The patient with HCL was a 69\u2010year\u2010old male. At the time of diagnosis of HCL, the patient had two solid tumors in the liver containing poorly differentiated epithelial carcinoma cells of unknown origin. During treatment with 2\u2010chlorodeoxyadenosine (2CdA), the tumors in the liver rapidly spread in multiple intrahepatic metastases, followed by liver failure and death within 1 month. Fludarabine and 2CdA cause a substantial suppression of all lymphocyte subsets, in particular the T\u2010cell line. T\u2010lymphocytes are believed to be responsible for the usually slow growth and the low metastatic rate of the SCC skin lesions. It is therefore assumed that fludarabine and 2CdA in these two cases triggered an exacerbation of both tumors due to the T\u2010cell depletion. Am. J. Hematol. 70:48\u201350, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10080","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:24:15Z","timestamp":1030317855000},"page":"48-50","source":"Crossref","is-referenced-by-count":19,"title":["Aggressive growth of epithelial carcinomas following treatment with nucleoside analogues"],"prefix":"10.1002","volume":"70","author":[{"given":"Christian Rifbjerg","family":"Larsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per Boye","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nielsaage T\u00f8ffner","family":"Clausen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,4,30]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"435","article-title":"Fludarabine phosphate: A DNA synthesis inhibitor with potent immunosuppressive activity and minimal clinical toxicity","volume":"62","author":"Goodman ER","year":"1996","journal-title":"Am Surg"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1200\/JCO.1991.9.1.175","article-title":"Fludarabine phosphate: a synthetic purine antimetabolite with significant activity against lymphoid malignancies","volume":"9","author":"Chung HG","year":"1991","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199509059649"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.4.1165"},{"key":"e_1_2_1_6_2","first-page":"4661","article-title":"Effects on human peripheral lymphocytes of in vivo administration of 9\u2010\u03b2\u2010D\u2010arabinofuranosyl\u20102\u2010luoroadenine\u20105\u2032\u2010monophosphate (NSC 312887), a new purine antimetabolite","volume":"44","author":"Boldt DH","year":"1984","journal-title":"Cancer Res"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1993.tb00165.x"},{"key":"e_1_2_1_8_2","first-page":"98","article-title":"The infectious complications of chronic lymphocytic leukemia","volume":"25","author":"Morrison VA","year":"1998","journal-title":"Semin Oncol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70001-V"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1992.tb07065.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.133.5.585"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.3.277"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1097\/00007611-200007000-00001","article-title":"Actinic keratosis is squamous cell carcinoma","volume":"93","author":"Lober BA","year":"2000","journal-title":"South Med J"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/lv.2000.6352"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70185-4"},{"key":"e_1_2_1_16_2","first-page":"28","article-title":"Skin cancers in organ transplant recipients","volume":"2","author":"Euvrard S","year":"1997","journal-title":"Ann Transplant"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.642"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000203561"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930330108"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.1999.00480.x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.8.2454"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.10080","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.10080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T12:58:03Z","timestamp":1700312283000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.10080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4,30]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["10.1002\/ajh.10080"],"URL":"https:\/\/doi.org\/10.1002\/ajh.10080","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4,30]]}}}