{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T18:45:27Z","timestamp":1761763527566},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,4,30]],"date-time":"2002-04-30T00:00:00Z","timestamp":1020124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral T\u2010cell proliferative disease\/lymphoma is a group of diseases which exhibits heterogeneity in clinical manifestations, pathological findings and outcomes. They are highly associated with the Epstein\u2010Barr virus (EBV) infection. It is likely that EBV plays an important role in the tumorigenesis. From January 1997 through April 2000, we identified 100 patients. One hundred healthy age\u2010 and sex\u2010 matched controls were selected. Serologic tests for the EBV infection and the study of EBV genomes in circulating non\u2010T cells (CD3<jats:sup>\u2212<\/jats:sup> cells), T cells (CD3<jats:sup>+<\/jats:sup> cells), and T\u2010cell subsets (CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> cells) were performed. The main features were prolonged fever, weight loss, hepatosplenomegaly, lymphadenopathy, multiorgan involvement, anemia, and high serum alkaline phosphatase and lactate dehydrogenase. Fifty\u2010one patients had an aggressive course and died; median survival was 21 months. Chemotherapy was not effective in improving survival. Anti\u2010viral capsid antigen\u2010IgG and anti\u2010early antigen\u2010IgG were significantly elevated, whereas there was no significant difference in anti\u2010EBV nuclear antigen. EBV internal repeat\u20101 region (IR\u20101) in the peripheral blood CD3<jats:sup>+<\/jats:sup> cells was detected in 65% of the patients but in none of the controls. For the CD3<jats:sup>\u2212<\/jats:sup> cells, EBV IR\u20101 was detected in 88% of the patients and 50% of the controls. Among twenty\u2010five patients whose CD3<jats:sup>+<\/jats:sup> cells were positive for EBV IR\u20101, 6 (24%) showed EBV IR\u20101 in only CD4<jats:sup>+<\/jats:sup> cells, 6 (24%) in only CD8<jats:sup>+<\/jats:sup> cells, and 13 (52%) in both CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> cells. The 30\u2010bp deletion variant of the EBV latent membrane protein\u20101 gene was significantly higher in the patients than in the controls. These data support the chronic infective process. The EBV which is dormant in non\u2010T cells may infect T cells and contribute to the pathogenesis of disease in a select group of patients. Am. J. Hematol. 70:31\u201338, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10094","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:24:15Z","timestamp":1030317855000},"page":"31-38","source":"Crossref","is-referenced-by-count":26,"title":["Epstein\u2010Barr virus\u2010associated peripheral T\u2010Cell and NK\u2010Cell proliferative disease\/lymphoma: clinicopathologic, serologic, and molecular 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