{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T00:04:00Z","timestamp":1700352240917},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,5,29]],"date-time":"2002-05-29T00:00:00Z","timestamp":1022630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report the case of a patient with lymphoma of the salivary gland, at first diagnosed as lymphoma of mucosa\u2010associated lymphoid tissue (MALT lymphoma) but later found to infiltrate the bone marrow. At diagnosis, the patient had a polyclonal increase of gamma\u2010globulins. Five years after initial diagnosis, the patient presented with monoclonal gammopathy and infiltration of the bone marrow with neoplastic cells. Initially, the patient had received chemotherapy with different protocols (including etoposide, cyclophosphamide, fludarabin, methotrexate, and vincristine), none of which induced a lasting response. Therapy with rituximab (chimeric anti\u2010CD20 monoclonal antibody) finally led to partial remission. Eighteen months after rituximab, progressive lymphoma in the abdomen and a monoclonal gammopathy developed. The bone marrow showed infiltration by lymphoplasmacytoid cells (monoclonal expression of the light\u2010chain type lambda, positive for CD20, heterogeneous expression of CD45). The patient achieved another short clinical response with 4 cycles of the CHOP\u2010protocol, but soon the lymphoma progressed again. Five years and 8 months after the initial diagnosis, the patient died from septicemia and progressive lymphoma. By polymerase chain reaction (PCR) for the IgH gene it was shown that lymphoma cells were initially oligoclonal in the salivary gland and, later, biclonal in the bone marrow. Sequencing of two bands of apparently same length showed that these manifestations of lymphoma were not identical. Taken together, our data show that the initial low\u2010grade oligoclonal MALT lymphoma was no longer present and a more aggressive biclonal lymphoma with plasmacytoid differentiation had developed. The new lymphoma was clonally distinct and produced high amounts of monoclonal IgG lambda by immunoelectrophoresis. The relationship of the second lymphoma to the initial MALT lymphoma is discussed. Am. J. Hematol. 70:167\u2013173, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10104","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T12:27:22Z","timestamp":1033907242000},"page":"167-173","source":"Crossref","is-referenced-by-count":3,"title":["Monoclonal gammopathy after low\u2010grade MALT lymphoma: Evidence for a second neoplasm"],"prefix":"10.1002","volume":"70","author":[{"given":"S.","family":"Pachmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Anderegg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"M\u00fcller\u2010H\u00f6cker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Nathrath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Brack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.J.","family":"Tigges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Hartenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Munker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,5,29]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"139","article-title":"Mucosa\u2010associated lymphoid tissue lymphoma","volume":"36","author":"Isaacson PG","year":"1999","journal-title":"Semin Hematol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.3.802.003k19_802_806"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1308"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2001.1.241"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00628-3"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90211-8"},{"key":"e_1_2_1_8_2","first-page":"763","article-title":"Second malignant neoplasms: clinical implications and basic research","volume":"9","author":"Munker R","year":"1996","journal-title":"Int J Oncol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.43.11.888"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960401)77:7<1349::AID-CNCR19>3.0.CO;2-1"},{"key":"e_1_2_1_11_2","first-page":"36","article-title":"Mucosal change of the stomach with low\u2010grade mucosa\u2010associated lymphoid tissue lymphoma after eradication of Helicobacter pylori: follow\u2010up study of 48 cases","volume":"47","author":"Begum S","year":"2000","journal-title":"J Med Invest"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.34.220"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1995.tb00299.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.18.1350"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70294-5"},{"key":"e_1_2_1_16_2","first-page":"277","article-title":"Immunoglobulin VH genes of high\u2010grade mucosa\u2010associated lymphoid tissue lymphomas show a high load of somatic mutations and evidence of antigen\u2010dependent affinity mutation","volume":"78","author":"Hallas C","year":"1998","journal-title":"Lab Invest"},{"key":"e_1_2_1_17_2","first-page":"155","article-title":"Classification of malignant lymphoma: the updated Kiel Classification","volume":"28","author":"Diebold J","year":"1997","journal-title":"Haematologica"},{"key":"e_1_2_1_18_2","first-page":"14","volume-title":"Extranodal lymphomas","author":"Isaacson PG","year":"1994"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/030089168306900417"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00708324"},{"key":"e_1_2_1_21_2","first-page":"221","article-title":"Immunocytoma, cancer and other associations of monoclonal gammopathy: a review of 224 cases","volume":"82","author":"Colls BM","year":"1975","journal-title":"N Z Med J"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.10104","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.10104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T10:03:19Z","timestamp":1700301799000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.10104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5,29]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["10.1002\/ajh.10104"],"URL":"https:\/\/doi.org\/10.1002\/ajh.10104","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5,29]]}}}