{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:45:54Z","timestamp":1791499554003,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,6,27]],"date-time":"2002-06-27T00:00:00Z","timestamp":1025136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Non\u2010hemolytic transfusion reactions (NHTR) occur in up to 30% of patients receiving platelet transfusions. Premedication with acetaminophen and diphenhydramine is a common strategy to prevent NHTR, but its efficacy has not been studied. In this prospective trial, transfusions in patients receiving pre\u2010storage leukocyte\u2010reduced single\u2010donor apheresis platelets (SDP) were randomized to premedication with either acetaminophen 650 mg PO and diphenhydramine 25 mg IV, or placebo. Fifty\u2010one patients received 98 transfusions. Thirteen patients had 15 NHTR: 15.4% (8\/52) in the treatment arm and 15.2% (7\/46) in the placebo arm. Premedication prior to transfusion of pre\u2010storage leukocyte reduced SDP does not significantly lower the incidence of NHTR as compared to placebo. Am. J. Hematol. 70:191\u2013194, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10119","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T11:34:39Z","timestamp":1033904079000},"page":"191-194","source":"Crossref","is-referenced-by-count":82,"title":["Acetaminophen and diphenhydramine as premedication for platelet transfusions: A prospective randomized double\u2010blind placebo\u2010controlled trial"],"prefix":"10.1002","volume":"70","author":[{"given":"Stephen E","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Primo N.","family":"Lara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angie","family":"Lee\u2010Ow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"Reed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori R.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patti","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Tuscano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol M.","family":"Richman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel","family":"Beckett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted","family":"Wun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,6,27]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1995.35295125733.x"},{"key":"e_1_2_1_3_2","first-page":"581","volume-title":"Goodman and Gilman's pharmacological basis of therapeutics","author":"Babe KS","year":"2001"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1990.30390194340.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-4541-9"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1996.36196190511.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1995.35295125744.x"},{"key":"e_1_2_1_8_2","first-page":"635","volume-title":"Principles of transfusion medicine","author":"Greenberger PA","year":"1991"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-199911000-00012"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1999.39399219278.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409083311001"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1993.331094054613.x"},{"key":"e_1_2_1_13_2","first-page":"617","volume-title":"Goodman and Gilman's pharmacological basis of therapeutics","author":"Insel PA","year":"2001"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40040439.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1999.39111179.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/95.5.733"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1982.tb01106.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1001\/jama.1991.03470040119033","article-title":"Septic reactions to platelet transfusions. 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