{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:25:34Z","timestamp":1790526334175,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T00:00:00Z","timestamp":1027641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The bcl\u20102 family of proteins comprises both antagonists and agonists of apoptosis. We have investigated whether subsets of indolent B\u2010cell non\u2010Hodgkin's lymphoma (IB\u2010NHL) differ in the expression of the bcl\u20102 family members; 116 cases of IB\u2010NHL, composed of chronic lymphocytic leukemia (CLL, <jats:italic>n<\/jats:italic> = 48), follicular lymphoma (FL, <jats:italic>n<\/jats:italic> = 38), marginal zone B\u2010cell lymphoma (MZBCL, <jats:italic>n<\/jats:italic> = 15), and mantle cell lymphoma (MCL, <jats:italic>n<\/jats:italic> = 15), were investigated for expression of bcl\u20102, bcl\u2010X, mcl\u20101, bax, and bak proteins by immunohistochemistry. Expression of bcl\u20102 and bcl\u2010X proteins was moderate\/high among most IB\u2010NHLs. Expression of mcl\u20101 was low\/absent in most cases of CLL and MCL and low\/moderate in most cases of FL and MZBCL. Most MCLs did not express bax protein. Bax expression was absent\/low among most cases of CLL and low\/moderate among most cases of FL and MZBCL. Expression of bak was moderate\/low among most cases of CLL, MZBCL, and MCL but was absent\/low among most cases of FL. The different subsets of IB\u2010NHLs differ in their expression of mcl\u20101, bax, and bak proteins. Am. J. Hematol. 70:278\u2013282, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10139","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T11:56:23Z","timestamp":1033905383000},"page":"278-282","source":"Crossref","is-referenced-by-count":43,"title":["Bcl\u20102 family of proteins in indolent B\u2010cell non\u2010Hodgkin's lymphoma: Study of 116 cases"],"prefix":"10.1002","volume":"70","author":[{"given":"Beamon","family":"Agarwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kikkeri N.","family":"Naresh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,7,26]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1693s","article-title":"Bcl\u20102 gene family and the regulation of programmed cell death","volume":"59","author":"Korsmeyer SJ","year":"1999","journal-title":"Cancer research"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-199901000-00014"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1309"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_1_6_2","first-page":"177","article-title":"Immunodetection of apoptosis\u2010regulating proteins in lymphomas from patients with and without human immunodeficiency virus infection","volume":"149","author":"Schlaifer D","year":"1996","journal-title":"Am J Pathol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70465-2"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008325827059"},{"key":"e_1_2_1_9_2","first-page":"515","article-title":"Immunohistochemical analysis of Mcl\u20101 and Bcl\u20102 proteins in normal and neoplastic lymph nodes","volume":"145","author":"Krajewski S","year":"1994","journal-title":"Am J Pathol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1182\/blood.V91.1.244","article-title":"Unbalanced expression of bcl\u20102 family proteins in follicular lymphoma: contribution of CD40 signalling in promoting survival","volume":"91","author":"Ghia P","year":"1998","journal-title":"Blood"},{"key":"e_1_2_1_11_2","first-page":"2403","article-title":"Expression of p53, p21, mdm2, Rb, bax and Ki67 proteins in lymphomas of the mucosa\u2010associated lymphoid (MALT) tissue","volume":"18","author":"Stefanaki K","year":"1998","journal-title":"Anticancer Res"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90451-8"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.423958.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.8.3173"},{"key":"e_1_2_1_15_2","first-page":"S60","article-title":"Mantle cell lymphoma: diagnostic criteria, clinical aspects and therapeutic problems","volume":"11","author":"Meusers P","year":"1997","journal-title":"Leukemia"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401533"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.14.5214"},{"key":"e_1_2_1_18_2","first-page":"573","article-title":"Cytogenetic 2;18 and 18;22 translocation in chronic lymphocytic leukemia with juxtaposition of bcl\u20102 and immunoglobulin light chain genes","volume":"7","author":"Tashiro S","year":"1992","journal-title":"Oncogene"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.6.1820.1820"},{"key":"e_1_2_1_20_2","first-page":"912","article-title":"CD40 ligand is constitutively expressed in a subset of T\u2010cell lymphomas and on the microenvironmental reactive T cells of follicular lymphomas and Hodgkin's disease","volume":"147","author":"Carbone A","year":"1995","journal-title":"Am J Pathol"},{"key":"e_1_2_1_21_2","first-page":"4610","article-title":"Expression of the Epstein Barr virus transforming protein LMP1 causes a rapid and transient stimulation of the Bcl\u20102 homologue Mcl\u20101 levels in B\u2010cell lines","volume":"56","author":"Wang S","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1309\/438N-E0FH-A5PR-XCAC"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.1998.13.269"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.10139","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.10139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T09:44:15Z","timestamp":1700300655000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.10139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7,26]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["10.1002\/ajh.10139"],"URL":"https:\/\/doi.org\/10.1002\/ajh.10139","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,7,26]]}}}