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The patient sustained a severe septic episode, was treated with antibiotics and GM\u2010CSF, and recovered the 14<jats:sup>th<\/jats:sup> day after ticlopidine withdrawal. The second was an 82\u2010year\u2010old man receiving ticlopidine for 2 years when, during a febrile episode, he was found neutropenic with marrow aplasia. Ticlopidine withdrawal and treatment with antibiotics, transfusions, and G\u2010CSF helped him to recover. When the data of the 57 patients are evaluated, a reversible direct cytotoxic effect of ticlopidine on the pluripotent\/bipotent hematopoietic progenitor stem cell is proposed. It is estimated that the real incidence if TIAA is higher, and many cases, initially presented as agranulocytosis \u00b1 thrombocytopenia, might be true aplastic anemias, not proven by marrow aspiration or trephine biopsy. There is no effective monitoring to prevent this side effect. Recombinant growth factors appear not to help in shortening the neutropenic period. Am. J. Hematol. 71:24\u201332, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10150","type":"journal-article","created":{"date-parts":[[2002,10,8]],"date-time":"2002-10-08T23:01:00Z","timestamp":1034118060000},"page":"24-32","source":"Crossref","is-referenced-by-count":28,"title":["Ticlopidine\u2010induced aplastic anemia: Two new case reports, review, and meta\u2010analysis of 55 additional 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