{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T12:41:58Z","timestamp":1700311318504},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,9,3]],"date-time":"2002-09-03T00:00:00Z","timestamp":1031011200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe the unique clinical characteristics of patients with idiopathic thrombocytopenic purpura (ITP) who are infected by human T\u2010lymphotropic virus type I (HTLV\u2010I). Thirty\u2010seven patients with ITP were examined in the present study: 10 patients had HTLV\u2010I infection, and the remaining 27 did not. The mean age of the group with HTLV\u2010I infection was significantly older than that of the group without infection (57.8 \u00b1 14.0 and 42.4 \u00b1 20.1, <jats:italic>P<\/jats:italic> = 0.022). The difference in mean platelet counts at diagnosis between the two groups was not significant, 29 \u00d7 10<jats:sup>9<\/jats:sup>\/L and 21 \u00d7 10<jats:sup>9<\/jats:sup>\/L, respectively. The levels of platelet associated IgG, red blood cell count, white blood cell count, bone marrow cell count, and megakaryocyte count did not show any significant difference. Nine patients in the group with HTLV\u2010I infection were treated with prednisolone (1 mg\/kg, daily oral). Only 3 of them responded to the therapy (one complete response [CR] and two partial responses [PR]). However, 17 of 22 patients not infected with HTLV\u2010I were treated with prednisolone successfully: 14 patients achieved CR, and 3 patients achieved PR. There was a significant difference in response to prednisolone between the two groups (<jats:italic>P<\/jats:italic> = 0.034). Two patients with the infection and one patient without the infection achieved CR with splenectomy. These results suggest that HTLV\u2010I infection may cause immune thrombocytopenia by a different mechanism than classical ITP; HTLV\u2010I may modify the clinical features of ITP through an unknown immune pathway. Am. J. Hematol. 71:20\u201323, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10173","type":"journal-article","created":{"date-parts":[[2002,10,8]],"date-time":"2002-10-08T23:01:00Z","timestamp":1034118060000},"page":"20-23","source":"Crossref","is-referenced-by-count":6,"title":["Poor response to prednisolone of idiopathic thrombocytopenia with human T\u2010lymphotropic virus type I infection"],"prefix":"10.1002","volume":"71","author":[{"given":"Kakushi","family":"Matsushita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomichi","family":"Arima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Ohtsubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosei","family":"Arimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimasa","family":"Kukita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuo","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiroh","family":"Hidaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuwa","family":"Tei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,9,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.6.2031"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410210203"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890380212"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1992.tb00092.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90038-X"},{"key":"e_1_2_1_7_2","first-page":"992","article-title":"HTLV\u2010I and polymyositis in Jamaica","author":"Morgan OS","year":"1989","journal-title":"Lancet"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980201)82:3<488::AID-CNCR10>3.0.CO;2-Y"},{"key":"e_1_2_1_9_2","first-page":"4718","article-title":"Association of human T\u2010cell leukemia virus and myelodysplastic syndrome in a central European population","volume":"57","author":"Karlic H","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830270215"},{"key":"e_1_2_1_11_2","first-page":"1655","article-title":"SLE, thrombocytopenia, and HTLV\u2010I","volume":"17","author":"Scott TF","year":"1990","journal-title":"J Rheumatol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199906)61:2<94::AID-AJH3>3.0.CO;2-V"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-104-1-47"},{"key":"e_1_2_1_14_2","first-page":"219","article-title":"Immunologic thrombocytopenic purpura in HIV\u2010seropositive homosexual, narcotic addicts and hemophilias","volume":"25","author":"Karpatkin S","year":"1988","journal-title":"Semin Hematol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1182\/blood.V88.1.3.3","article-title":"Idiopathic thrombocytopenic purpura: a practical guideline developed by explicit methods for the American Society of Hematology","volume":"88","author":"George NJ","year":"1996","journal-title":"Blood"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6476"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1128\/jcm.26.2.308-312.1988","article-title":"Comparative studies of commercially available particle agglutination assay and enzyme\u2010linked immunosorbent assay for screening of human T\u2010cell leukemia virus type I antibodies in blood donors","volume":"26","author":"Kobayahi S","year":"1988","journal-title":"J Clin Microbiol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1887217"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910610105"},{"key":"e_1_2_1_20_2","first-page":"46","volume-title":"Reports of a study on adult T\u2010cell leukemia in Kagoshima Prefecture","author":"Kagoshima Prefectural Government","year":"1996"},{"key":"e_1_2_1_21_2","first-page":"300","article-title":"Splenectomy for immune thrombocytopenia related to human immunodeficiency virus","volume":"167","author":"Ferguston CM","year":"1988","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.4049\/jimmunol.138.9.3069","article-title":"Heterogeneity in response to interleukin\u20102 and interleukin 2\u2010producing ability of adult T\u2010cell leukemia cells","volume":"138","author":"Arima N","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(96)00109-9"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2000.02257.x"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.10173","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.10173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T22:23:43Z","timestamp":1700259823000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.10173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["10.1002\/ajh.10173"],"URL":"https:\/\/doi.org\/10.1002\/ajh.10173","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}