{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:49:32Z","timestamp":1791089372649,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,9,26]],"date-time":"2002-09-26T00:00:00Z","timestamp":1032998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although the common 4G\/5G polymorphism in the promoter of the PAI\u20101 gene was suggested to be a risk factor for some of the thrombotic disorders, its significance in the development of thrombosis is still controversial. This study presents the data on a total of 357 patients with different types of thrombosis and 281 unrelated healthy controls. It was found that the 4G\/4G genotype is associated with a higher risk of thrombosis (OR, 1.7; 95% CI, 1.1\u20132.5). Patients were divided into five distinct groups according to the site of thrombosis. Both 4G\/4G and 4G\/5G genotypes were associated with a higher risk of thrombosis development in a group of 69 patients with internal organ thrombosis (OR, 6.35; 95% CI, 2.5\u201316.1 and OR, 4.85; 95% CI, 2.0\u201312.1, respectively). Interestingly, this association was even stronger in a subgroup of 33 patients with portal vein thrombosis (PVT) and 4G\/4G and 4G\/5G genotypes conferred more than 10\u2010 and 6\u2010fold increases in the risk of developing PVT (95% CI: 2.3\u201347.1 and 1.4\u201328.8), respectively. No statistically significant association was found between 4G\/4G genotype and the groups of deep vein thrombosis (126 patients), cerebral thrombosis (80 patients), retinal thrombosis (72 patients), and purpura fulminans (16 patients). Factor V Leiden or prothrombin G20210A mutations did not emerge as additional risk factors for thrombosis in any of the groups studied. To conclude, this study suggests that there may be an association between 4G\/4G and 4G\/5G genotypes and the thrombosis in vessels of internal organs especially in the portal veins. Am. J. Hematol. 71:89\u201393, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10192","type":"journal-article","created":{"date-parts":[[2002,10,9]],"date-time":"2002-10-09T04:26:45Z","timestamp":1034137605000},"page":"89-93","source":"Crossref","is-referenced-by-count":80,"title":["PAI\u20101 gene 4G\/5G genotype: A risk factor for thrombosis in vessels of internal organs"],"prefix":"10.1002","volume":"71","author":[{"given":"Gunay","family":"Balta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cigdem","family":"Altay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aytemiz","family":"Gurgey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,9,26]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006153422406"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"10739","DOI":"10.1016\/S0021-9258(18)82047-6","article-title":"The two allele sequences of a common polymorphism in the promoter of the plasminogen activator inhibitor\u20101 (PAI\u20101) gene respond differently to interleukin\u20101 in HepG2 cells","volume":"25","author":"Dawson SJ","year":"1993","journal-title":"J Biol Chem"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.6.1851"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)09376-3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199909000-00017"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100380050200"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00884.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1055\/s-0037-1615068","article-title":"A common 4G allele in the promoter of the plasminogen activator inhibitor\u20101 (PAI\u20101) gene as a risk factor for pulmonary embolism and arterial thrombosis in hereditary protein S deficiency","volume":"79","author":"Zoller B","year":"1998","journal-title":"Thromb Haemost"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614639"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(00)00236-X"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/369064a0"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1182\/blood.V88.10.3698.bloodjournal88103698","article-title":"A common genetic variation in the 3\u2032\u2010untranslated region of the prothrombin gene is associated with elevated prothrombin levels and an increase in venous thrombosis","volume":"88","author":"Poort SR","year":"1996","journal-title":"Blood"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.9.1862"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.1.67"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(99)00164-4"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2000.02321.x"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.10192","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.10192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T07:57:50Z","timestamp":1700294270000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.10192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9,26]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["10.1002\/ajh.10192"],"URL":"https:\/\/doi.org\/10.1002\/ajh.10192","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9,26]]}}}