{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:03:48Z","timestamp":1777575828953,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,11,22]],"date-time":"2002-11-22T00:00:00Z","timestamp":1037923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Induction of tolerance in solid organ transplant recipients has been a long sought goal so that patients will not need lifelong immunosuppression. In this case report we review a patient who received a kidney transplant from an HLA matched related sibling and developed acute leukemia as a consequence of her immunosuppression. The patient was then treated with an allogeneic bone marrow transplant from her kidney donor. After the bone marrow transplant, all immunosuppression therapy for graft rejection and graft versus host disease was stopped. Six months after the bone marrow transplant, the patient's kidney function had no deterioration as a consequence of stopping immunosuppression. This illustrated that a combined solid organ\/bone marrow transplant can help to induce tolerance. In fact, the tolerance to the bone marrow transplant for prevention of graft versus host disease may have been accomplished by the prior kidney transplant. Am. J. Hematol. 71:311\u2013313, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10206","type":"journal-article","created":{"date-parts":[[2002,11,25]],"date-time":"2002-11-25T13:57:37Z","timestamp":1038232657000},"page":"311-313","source":"Crossref","is-referenced-by-count":12,"title":["Discontinuation of immunosuppression for prevention of kidney graft rejection after receiving a bone marrow transplant from the same HLA identical sibling donor"],"prefix":"10.1002","volume":"71","author":[{"given":"James L.","family":"Gajewski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Ippoliti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Champlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199310000-00033"},{"key":"e_1_2_1_3_2","first-page":"3082","article-title":"Role of cyclosporin: present and future","volume":"26","author":"Kahan BD","year":"1994","journal-title":"Transplant Proc"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0966-3274(95)80010-7"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0967-2109(98)00027-1"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/172603a0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199101000-00011"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199809000-00005"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199501000-00018"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199701150-00003"},{"key":"e_1_2_1_11_2","first-page":"1633","article-title":"Renal transplantation without chronic immunosuppression after T\u2010cell depleted, HLA\u2010mismatched bone marrow transplantation","volume":"59","author":"Sorof JM","year":"1995","journal-title":"Transplantation"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-6-498_1"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0797-783"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-3-269"},{"key":"e_1_2_1_15_2","first-page":"1420","article-title":"Renal transplantation without immunosuppression in a host with tolerance induced by allogeneic BMT","volume":"58","author":"Helg C","year":"1994","journal-title":"Transplantation"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V67.3.811.811"},{"key":"e_1_2_1_17_2","first-page":"304","article-title":"Low intensity regimens with allogeneic hematopoietic stem cell transplantation treatment of hematologic neoplasia","volume":"85","author":"Carella AM","year":"2000","journal-title":"Haemtologica"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.4049\/jimmunol.153.3.1087","article-title":"Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with non\u2010myeloablative regimen","volume":"153","author":"Tomita Y","year":"1994","journal-title":"J Immunol"},{"key":"e_1_2_1_19_2","first-page":"3483","article-title":"Transplantation of a lobe of lung from mother to child following previous transplantation with maternal bone marrow","volume":"27","author":"Svendsen U","year":"1995","journal-title":"Transplant Proc"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-11-954"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.10206","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.10206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T12:40:01Z","timestamp":1700397601000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.10206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11,22]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["10.1002\/ajh.10206"],"URL":"https:\/\/doi.org\/10.1002\/ajh.10206","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11,22]]}}}