{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:39:19Z","timestamp":1790177959908,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,10,30]],"date-time":"2002-10-30T00:00:00Z","timestamp":1035936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe a 17\u2010year\u2010old woman with chronic active Epstein\u2010Barr virus infection (CAEBV), who developed EBV<jats:sup>+<\/jats:sup>CD4<jats:sup>\u2212<\/jats:sup>CD8<jats:sup>\u2212<\/jats:sup> T\u2010cell polymyositis. At 14 years of age, CAEBV was diagnosed with fever, cytopenia, liver dysfunction, and hepatosplenomegaly. Despite the transient remission of interferon\u2010\u03b1 therapy, migratory lesions emerged in back and extremities. MRI indicated polymyositis. Biopsy specimens revealed intramuscular infiltration of CD3<jats:sup>+<\/jats:sup>, CD4<jats:sup>\u2212<\/jats:sup>, CD8<jats:sup>\u2212<\/jats:sup>, CD56<jats:sup>\u2212<\/jats:sup>, and EBV\u2010encoded RNA 1<jats:sup>+<\/jats:sup> cells. Circulating CD4<jats:sup>\u2212<\/jats:sup>CD8<jats:sup>\u2212<\/jats:sup>V\u03b42\/V\u03b39 cells increased. \u03b3\u03b4T\u2010cells contained 20\u2013200 times higher EBV\u2010DNA (2 \u00d7 10<jats:sup>4<\/jats:sup> copies\/\u03bcgDNA) than \u03b1\u03b2T\u2010cells or NK\u2010cells. The ominous polymyositis might denote the musculotropic invasion of EBV<jats:sup>+<\/jats:sup>\u03b3\u03b4T\u2010cell lymphoproliferative disease as a consequence of CAEBV. Am. J. Hematol. 71:211\u2013215, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10207","type":"journal-article","created":{"date-parts":[[2002,10,31]],"date-time":"2002-10-31T18:20:30Z","timestamp":1036088430000},"page":"211-215","source":"Crossref","is-referenced-by-count":17,"title":["CD4<sup>\u2212<\/sup>CD8<sup>\u2212<\/sup> T\u2010cell polymyositis in a patient with chronic active Epstein\u2010Barr virus infection"],"prefix":"10.1002","volume":"71","author":[{"given":"Sachiko","family":"Tsutsumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouichi","family":"Ohga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Takada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotoko","family":"Sumimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,10,30]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008173430707"},{"key":"e_1_2_1_3_2","first-page":"108","article-title":"Epstein\u2010Barr 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