{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:49:02Z","timestamp":1761742142189},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,11,22]],"date-time":"2002-11-22T00:00:00Z","timestamp":1037923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report the case of a 40\u2010year\u2010old African\u2010American female who presented to the Emergency Department with unstable angina. The patient, who had multiple risk factors for coronary artery disease, was admitted to the coronary care unit for cardiac work\u2010up and management. Shortly after the intravenous administration of unfractionated heparin, she suffered the acute onset of upper abdominal pain and shock. A CT scan of the abdomen revealed splenic rupture with hemoperitoneum. The patient, who was managed surgically, had complete recovery before discharge. A review of systems and medical records revealed no obvious risk factors or other potential etiology for this rupture. We herein provide the characteristics of this rarely documented causal relationship between heparin and spontaneous splenic rupture and retrospectively review similar cases in the literature. Am. J. Hematol. 71:314\u2013317, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10214","type":"journal-article","created":{"date-parts":[[2002,11,25]],"date-time":"2002-11-25T13:57:37Z","timestamp":1038232657000},"page":"314-317","source":"Crossref","is-referenced-by-count":18,"title":["Spontaneous splenic rupture following the administration of intravenous heparin: Case report and retrospective case review"],"prefix":"10.1002","volume":"71","author":[{"given":"Michel W.","family":"Ghobrial","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Karim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunitha","family":"Mannam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,11,22]]},"reference":[{"issue":"1","key":"e_1_2_1_2_2","first-page":"119","article-title":"Heparin and low\u2010molecular\u2010weight heparin: mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy, and safety","author":"Hirsh J","year":"2001","journal-title":"Chest"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.18.2310"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.24.2994"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.5.1418"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.1_suppl.108S"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(93)90156-J"},{"key":"e_1_2_1_8_2","first-page":"961","article-title":"Hemorragie gravissime par rupture d'hematome souscapsulaire rate saine au cours d'heparinisation pour desobliteration arterielle","volume":"64","author":"Arnulf G","year":"1968","journal-title":"Lyon Chirurgical"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02735583"},{"key":"e_1_2_1_10_2","first-page":"107","article-title":"Spontaneous splenic rupture due to heparin. 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