{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T19:56:17Z","timestamp":1760644577516},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,11,22]],"date-time":"2002-11-22T00:00:00Z","timestamp":1037923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CD5\u2010 and CD10\u2010negative chronic lymphocytic leukemias are quite uncommon as compared to the CD5\u2010positive CLL. We reviewed 250 sequential cases of peripheral blood lymphocytosis to characterize cases of small B\u2010cell lymphoproliferative disorders, submitted with a clinical diagnosis of chronic lymphocytic leukemia exhibiting a non\u2010classic immunophenotypic profile. Six cases of CD5\u2010, CD10\u2010negative chronic lymphocytic leukemias and no tissue involvement were identified that revealed high\u2010density surface\u2010membrane immunoglobulin and CD20 expression, with variable expression of CD11c, CD23, and CD25. Most had a profound leukocytosis (mean WBC 180 \u00d7 10<jats:sup>9<\/jats:sup>\/L) with proliferation of mature\u2010appearing lymphocytes. Subsequent bone marrow biopsies showed diffuse infiltration by neoplastic cells in all evaluated patients. The clinical course appeared indolent, with follow\u2010up revealing three patients alive (survival time 38\u201368 months), while two died of unrelated causes and one was lost to follow\u2010up soon after diagnosis. These cases may represent somewhat unusual chronic lymphoproliferative disorders, with morphologic features and immunophenotypic profile not readily classifiable, but which are certainly atypical for classic chronic lymphocytic leukemia. Some of these features are reminiscent of those seen in marginal\u2010zone lymphoma. However, it is most unusual for this known to be tissue\u2010based disease to present primarily as leukemia rather than lymphoma. Am. J. Hematol. 71:306\u2013310, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10222","type":"journal-article","created":{"date-parts":[[2002,11,25]],"date-time":"2002-11-25T13:57:37Z","timestamp":1038232657000},"page":"306-310","source":"Crossref","is-referenced-by-count":22,"title":["CD5\u2010Negative, CD10\u2010Negative small B\u2010cell leukemia: Variant of chronic lymphocytic leukemia or a distinct entity?"],"prefix":"10.1002","volume":"71","author":[{"given":"Salwa S.","family":"Sheikh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhaskar V.S.","family":"Kallakury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khawla 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