{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:20:13Z","timestamp":1779301213402,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,11,22]],"date-time":"2002-11-22T00:00:00Z","timestamp":1037923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>From 1986 to 1998, 26 (23%) of 114 adult acute lymphoblastic leukemia (ALL) patients and 11 (4%) of 328 pediatric patients were found to have Philadelphia (Ph) chromosome. In the 30 patients with available data at diagnosis, 18 (60%) had extra\u2010chromosomal abnormalities. They included 1q duplication (5\/18, 28%), supernumerary Ph chromosome (4\/18, 22%), 9p abnormalities (3\/18, 17%), 7q deletion\/monosomy 7 (3\/18, 17%), trisomy 19 (1\/18, 6%), and trisomy 8 (1\/18, 6%). Excluding those with specific cytogenetic changes, only one patient had hyperdiploid karyotype with more than 50 chromosomes. The incidence of 1q duplication was higher and that of hyperdiploidy was lower in this study than has been previously reported. There was no prognostic implication of these additional cytogenetic abnormalities. With fluorescence in situ hybridization (FISH) and reverse transcription\u2010polymerase chain reaction (RT\u2010PCR), 14 (27%) of 53 unselected adult ALL patients and 2 (5%) of 38 unselected pediatric patients were BCR\u2010ABL\u2010positive, including one adult and two children without Ph chromosome. The BCR\u2010ABL fusion genes\/transcripts were also present in all other 16 selected Ph\u2010positive ALL patients. The BCR\u2010ABL fusion subtypes were determined in all these 32 patients: 91% (11\/12) childhood cases showed m\u2010type fusion gene while 45% (9\/20) adult ones did so (<jats:italic>P<\/jats:italic> = 0.0083). The clinical outcome was similar between the two groups of patients with m\u2010type and M\u2010type BCR\u2010ABL. In conclusion, both cytogenetic and molecular studies are very helpful for identifying the subgroup of ALL patients with Ph\/BCR\u2010ABL. The additional cytogenetic abnormalities and subtypes of BCR\u2010ABL fusion genes\/transcripts had no significant implications in this group of patients. Am. J. Hematol. 71:291\u2013299, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10227","type":"journal-article","created":{"date-parts":[[2002,11,25]],"date-time":"2002-11-25T13:57:37Z","timestamp":1038232657000},"page":"291-299","source":"Crossref","is-referenced-by-count":28,"title":["Additional chromosomal abnormalities and variability of BCR breakpoints in Philadelphia chromosome\/BCR\u2010ABL\u2010positive acute lymphoblastic leukemia in Taiwan"],"prefix":"10.1002","volume":"71","author":[{"given":"Bor\u2010Sheng","family":"Ko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jih\u2010Lu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen\u2010Yu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Chi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woei","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao\u2010Chang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiu\u2010Hwa","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Chin","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Tsam","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai\u2010Hsin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwei\u2010Fang","family":"Tien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,11,22]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1497","article-title":"A 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