{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:39:52Z","timestamp":1777351192844,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,11,22]],"date-time":"2002-11-22T00:00:00Z","timestamp":1037923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Over the past decade, invasive fungal infections have become an increasingly important problem in patients undergoing hematopoietic stem cell transplantation (HSCT). The optimal approach for prophylactic antifungal therapy has yet to be determined. To resolve this issue, we performed a prospective randomized study to compare the efficacy of fluconazole (FL) versus low\u2010dose amphotericin B (AmB) in preventing fungal infections during the first 100 days after HSCT. Patients undergoing allogenic or autologous HSCT were randomized to receive fluconazole 200 mg\/day PO or amphotericin B 0.2 mg\/kg\/day IV beginning 1 day prior to commencement of conditioning regimen and continuing until engraftment, drug\u2010associated toxicity was suspected, or systemic fungal infection was suspected or proven. High\u2010dose amphotericin B (0.5\u20131.0 mg\/kg\/day) was started for patients with suspected or proven fungal infections. From January 1993 to December 1998, a total of 186 patients were enrolled into the trial, with 100 receiving FL and 86 receiving AmB. Eighty (43%) patients were removed from prophylaxis for persistent fever despite broad\u2010spectrum antibacterial therapy or suspected fungal infections (FL 46 vs. AmB 34, <jats:bold>P<\/jats:bold> &gt; 0.05). The incidence of proven fungal infections (FL 12% vs. AmB 12.8%), suspected fungal infections (FL 4% vs. AmB 2.3%), superficial fungal infections (FL 1% vs. AmB 4.6%) did not show any significant difference. The survival at 100 days post transplant was similar between the 2 groups (FL 78% vs. AmB 70%, <jats:bold>P<\/jats:bold> = 0.254). Death attributable to fungal infections was similar in both groups (6% vs. 7%, <jats:bold>P<\/jats:bold> &gt; 0.05). We conclude that fluconazole is as effective as low\u2010dose amphotericin B in prophylaxis against fungal infections in patients undergoing hematopoietic cell transplantation. Am. J. Hematol. 71:260\u2013267, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10234","type":"journal-article","created":{"date-parts":[[2002,11,25]],"date-time":"2002-11-25T13:57:37Z","timestamp":1038232657000},"page":"260-267","source":"Crossref","is-referenced-by-count":49,"title":["Randomized trial of fluconazole versus low\u2010dose amphotericin B in prophylaxis against fungal infections in patients undergoing hematopoietic stem cell 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