{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:44:44Z","timestamp":1790117084279,"version":"4.0.1"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,12,30]],"date-time":"2002-12-30T00:00:00Z","timestamp":1041206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Severe neutropenia following cytotoxic, anti\u2010cancer chemotherapy is well\u2010known to be associated with an increased risk of infections that may be life\u2010threatening, particularly if not treated immediately. Consequently, serial measurements of neutrophil counts in peripheral blood are done routinely following the administration of high\u2010dose myelosuppressive chemotherapy in order to monitor the onset, severity, and duration of iatrogenic neutropenia. We have studied a non\u2010invasive method of quantifying neutrophils recoverable from the oral mucosa, a normal tissue site of neutrophil turnover, as an alternative approach for monitoring severe, chemotherapy\u2010induced neutropenia. This method is based on the quantification of fluorochrome\u2010stained neutrophils present in timed mouthwash specimens. Blood neutrophil (ANC) and mucosal neutrophil counts (MNC) were measured repeatedly in 23 patients who had been treated with dose\u2010intensive chemotherapy for a variety of indications. All 23 patients developed profound neutropenia (ANC &lt; 100\/mm<jats:sup>3<\/jats:sup>), and 19 developed neutropenic fever (&gt;101\u00b0F) during the 2 weeks following treatment. Nadirs of neutropenia defined by MNC were significantly less prolonged than those defined by the ANC. Furthermore, the onset and resolution of neutropenic fever coincided more precisely with nadirs of neutropenia defined by the MNC than with those defined by the ANC. Our findings indicate that oral mucosal neutrophil counts predict the timing of clinical events associated with neutropenia (e.g., the onset and resolution of fever) with significantly greater accuracy than blood neutrophil counts. Am. J. Hematol. 72:13\u201319, 2003. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10250","type":"journal-article","created":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T02:20:13Z","timestamp":1041387613000},"page":"13-19","source":"Crossref","is-referenced-by-count":22,"title":["Use of oral mucosal neutrophil counts to detect the onset and resolution of profound neutropenia following high\u2010dose myelosuppressive chemotherapy"],"prefix":"10.1002","volume":"72","author":[{"given":"Gorgun","family":"Akpek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,12,30]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-64-2-328"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)31284-6"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199305063281808"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V67.4.1023.1023"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1992.tb06472.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.11.3302.010k35_3302_3309"},{"key":"e_1_2_1_8_2","first-page":"359","article-title":"The kinetics of neutrophilic leukocytes in health and disease","volume":"4","author":"Boggs DR","year":"1967","journal-title":"Semin Hematol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.123.6.722"},{"key":"e_1_2_1_10_2","first-page":"614","article-title":"Marginal neutrophil pool size in normal subjects and neutropenic patients as measured by epinephrine infusion","volume":"88","author":"Joyce RA","year":"1976","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1963.tb01803.x"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.10250","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.10250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T23:53:59Z","timestamp":1700265239000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.10250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12,30]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1002\/ajh.10250"],"URL":"https:\/\/doi.org\/10.1002\/ajh.10250","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12,30]]}}}