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Platelet count was 3.5 \u00d7 10<jats:sup>6<\/jats:sup>\/\u03bcL, and despite plateletpheresis, the patient required left\u2010leg amputation. Pathologic examination was remarkable for arterial thrombosis in the absence of atherosclerotic lesions. A diagnosis of acute myeloid leukemia with a novel translocation between chromosomes 3q21, 16, and 7 was made. Induction therapy was unsuccessful, and the patient died of overwhelming sepsis within 5 weeks of diagnosis. The striking features of this case were extreme symptomatic thrombocytosis, peripheral gangrene without atherosclerosis, and a novel three\u2010way chromosomal translocation involving chromosome 3q21. Am. J. Hematol. 72:20\u201326, 2003. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10256","type":"journal-article","created":{"date-parts":[[2002,12,31]],"date-time":"2002-12-31T21:20:13Z","timestamp":1041369613000},"page":"20-26","source":"Crossref","is-referenced-by-count":12,"title":["Acute myelogenous leukemia associated with extreme symptomatic thrombocytosis and chromosome 3q translocation: Case report and review of literature"],"prefix":"10.1002","volume":"72","author":[{"given":"Victor T.","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Aviv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie 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