{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T03:30:33Z","timestamp":1770348633992,"version":"3.49.0"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,2,25]],"date-time":"2003-02-25T00:00:00Z","timestamp":1046131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A deficiency in airway nitric oxide (NO) could contribute to pulmonary vaso\u2010occlusion in sickle cell disease (SCD). We measured the fractional expired concentration of NO (FE<jats:sub>NO<\/jats:sub>) by chemiluminescence during a slow vital capacity maneuver against a positive pressure of 16 cm H<jats:sub>2<\/jats:sub>O at an expiratory flow rate of 50 mL\/sec in 44 stable ambulatory adults with SCD and 30 healthy controls. A history of acute chest syndrome was present in 29 patients, and 22 complained of dyspnea. Mean \u00b1 SD FE<jats:sub>NO<\/jats:sub> was significantly reduced in the SCD group compared with controls (14.8 \u00b1 8.4 vs. 24.9 \u00b1 13.5 ppb, <jats:italic>P<\/jats:italic> &lt; 0.001). SCD patients with dyspnea had lower FE<jats:sub>NO<\/jats:sub> than those without dyspnea (10.1 \u00b1 5.7 vs. 19.6 \u00b1 8 ppb, <jats:italic>P<\/jats:italic> &lt; 0.001) and those with a history of ACS had lower values than those no episodes of ACS (13.0 \u00b1 8.3 vs. 18.4 \u00b1 7.6 ppb, <jats:italic>P<\/jats:italic> &lt; 0.05). There was a weak correlation between FE<jats:sub>NO<\/jats:sub> and percent\u2010predicted DLCO (<jats:italic>r<\/jats:italic> = 0.4, <jats:italic>P<\/jats:italic> = 0.02) among the SCD patients. We conclude that exhaled NO is reduced in adults with SCD, and this may play a role in the pathogenesis of acute chest syndrome and chronic sickle cell lung disease. Am. J. Hematol. 72:177\u2013184, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10284","type":"journal-article","created":{"date-parts":[[2003,3,18]],"date-time":"2003-03-18T23:06:31Z","timestamp":1048028791000},"page":"177-184","source":"Crossref","is-referenced-by-count":41,"title":["Decreased exhaled nitric oxide in sickle cell disease: Relationship with chronic lung involvement"],"prefix":"10.1002","volume":"72","author":[{"given":"Reda E.","family":"Girgis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed A.","family":"Qureshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Abrams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Swerdlow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,2,25]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406093302303"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2143(97)90176-1"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711273372203"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.1.9611085"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.6.1584"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200103000-00009"},{"issue":"2","key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1152\/jappl.1996.80.2.531","article-title":"Pulmonary entrapment of sickle cells: the role of regional alveolar hypoxia","volume":"80","author":"Aldrich TK","year":"1996","journal-title":"J Appl Physiol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.1.249"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.11.2104101"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198801000-00005"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90760-9"},{"issue":"4","key":"e_1_2_1_13_2","first-page":"H1579","article-title":"Endothelial cell nitric oxide production in acute chest syndrome","volume":"277","author":"Hammerman SI","year":"1999","journal-title":"Am J Physiol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0037-1963(01)90027-7"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(200004)63:4<200::AID-AJH7>3.0.CO;2-Q"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1378"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.5.1629"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.2.9909105"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.52.12.1051"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.3.9802066"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006223422502"},{"issue":"6","key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1164\/ajrccm.160.6.ats8-99","article-title":"Recommendations for standardized procedures for the on\u2010line and off\u2010line measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide in adults and children\u20141999. 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