{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T02:32:51Z","timestamp":1763346771326},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,3,21]],"date-time":"2003-03-21T00:00:00Z","timestamp":1048204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic lymphocytic leukemia (CLL) is rarely associated with Hodgkin's disease (HD). We report a case of nodular sclerosis HD in a patient previously diagnosed with CLL. Reed\u2010Sternberg cells were CD15<jats:sup>+<\/jats:sup> and CD30<jats:sup>+<\/jats:sup>. He was treated with dose\u2010escalated CHOP and at relapse, mitoxantrone, vinblastine, and CCNU (MVC) with partial response to the former and complete response to the latter, although the patient died 15 months later. Data from 88 other similar cases published in the English language were analyzed. Based on the histological and clinical features at the time of transformation, these patients were divided into distinct categories for analysis. Prognosis was found to be poorer in patients with continued active CLL when compared with those with CLL in remission at the time of transformation to HD. It is suggested that these two presentations may derive from different pathogenic mechanisms. Am. J. Hematol. 72:267\u2013273, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10300","type":"journal-article","created":{"date-parts":[[2003,3,25]],"date-time":"2003-03-25T11:59:13Z","timestamp":1048593553000},"page":"267-273","source":"Crossref","is-referenced-by-count":23,"title":["Partially successful treatment of a patient with chronic lymphocytic leukemia and Hodgkin's disease: Case report and literature review"],"prefix":"10.1002","volume":"72","author":[{"given":"Giridhar U.","family":"Adiga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lool","family":"Abebe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H.","family":"Wiernik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,3,21]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1182\/blood.V91.5.1757","article-title":"Origin of the Hodgkin\/Reed\u2010Sternberg cells in chronic lymphocytic leukemia with \u201cHodgkin's transformation\u201d","volume":"91","author":"Ohno T","year":"1998","journal-title":"Blood"},{"key":"e_1_2_1_3_2","first-page":"254","article-title":"Mitoxantrone, vinblastine, and lomustine (CCNU) (MVC): a highly active regimen for advanced and poor\u2010prognosis Hodgkin's disease","volume":"4","author":"Wiernik PH","year":"1998","journal-title":"Cancer J Sci Am"},{"key":"e_1_2_1_4_2","first-page":"3907","article-title":"Implication of the Epstein\u2010Barr Virus in the progression of chronic lymphocytic leukemia\/small lymphocytic lymphoma to Hodgkin\u2010like lymphomas","volume":"17","author":"Petrella T","year":"1997","journal-title":"Anticancer Res"},{"key":"e_1_2_1_5_2","first-page":"386","article-title":"A case of composite Hodgkin's disease and chronic lymphocytic leukemia in bone marrow. Lack of Epstein\u2010Barr virus","volume":"120","author":"Cha I","year":"1996","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1182\/blood.V95.3.1023.003k07_1023_1031","article-title":"Hodgkin and Reed\u2010Sternberg\u2010like cells in B\u2010cell chronic lymphocytic leukemia represent the outgrowth of single germinal center B\u2010cell\u2010derived clones: potent precursors of Hodgkin and Reed\u2010Sternberg cells in Hodgkin's disease","volume":"95","author":"Kanzler H","year":"2000","journal-title":"Blood"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830480220"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(05)80443-5"},{"key":"e_1_2_1_9_2","first-page":"2537","article-title":"Large cell Non\u2010Hodgkin's lymphoma and Hodgkin's disease arising synchronously in a patient with chronic lymphocytic leukemia: importance of immunocytochemistry","volume":"94","author":"Gopal AK","year":"1999","journal-title":"Blood"},{"key":"e_1_2_1_10_2","first-page":"91","article-title":"Richter's transformation of chronic lymphocytic leukemia with Hodgkin's\u2010like cells associated with Epstein\u2010Barr virus infection","volume":"7","author":"Rubin DS","year":"1994","journal-title":"Mod Pathol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810701)48:1<48::AID-CNCR2820480112>3.0.CO;2-#"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01744374"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199101000-00004"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004280000214"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000332710"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/93.3.333"},{"key":"e_1_2_1_17_2","first-page":"878","article-title":"Chronic lymphocytic leukemia and Hodgkin's disease. Clinicopathologic study of three cases with good prognosis","volume":"85","author":"Serratrice De Roux C","year":"2000","journal-title":"Haematologica"},{"key":"e_1_2_1_18_2","first-page":"205","article-title":"Chronic lymphocytic leukemia and Hodgkin's disease in the same patient: a report of two cases","volume":"35","author":"Leahu S","year":"1989","journal-title":"Morphol Embryol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401389"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950090310"},{"key":"e_1_2_1_21_2","first-page":"1801","article-title":"Case records of the Massachusetts General Hospital\u2014weekly clinicopathological exercises","volume":"327","author":"Scully RE","year":"1992","journal-title":"New Engl J Med"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199609054836"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/103.4.479"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199209000-00004"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","first-page":"907","DOI":"10.5858\/2000-124-0907-CPAHTO","article-title":"Composite prolymphocytoid and Hodgkin transformation of chronic lymphocytic leukemia","volume":"124","author":"O'Sullivan MJ","year":"2000","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_26_2","first-page":"12","article-title":"Simultaneous occurrence of Hodgkin's disease and chronic lymphocyte leukemia: a unique presentation","volume":"92","author":"Acaba L","year":"2000","journal-title":"Bol Asoc Med P R"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197108)28:2<300::AID-CNCR2820280207>3.0.CO;2-7"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1989.tb03039.x"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1385\/MO:19:2:109"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.2.207"},{"key":"e_1_2_1_31_2","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1182\/blood.V100.4.1425.h81602001425_1425_1429","article-title":"Clonal relation in a case of CLL, ALCL, and Hodgkin composite lymphoma","volume":"100","author":"van den Berg A","year":"2002","journal-title":"Blood"},{"key":"e_1_2_1_32_2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1001\/jama.1975.03250030023012","article-title":"Subsequent neoplasia in chronic lymphocytic leukemia","volume":"232","author":"Manusow D","year":"1975","journal-title":"J Am Med Assoc"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199902)60:2<99::AID-AJH3>3.0.CO;2-T"},{"key":"e_1_2_1_34_2","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1182\/blood.V92.4.1165","article-title":"Long\u2010term follow up of patients with chronic lymphocytic leukemia receiving fludarabine regimen as initial therapy","volume":"92","author":"Keating MJ","year":"1998","journal-title":"Blood"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.10300","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.10300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T15:30:57Z","timestamp":1700235057000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.10300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3,21]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["10.1002\/ajh.10300"],"URL":"https:\/\/doi.org\/10.1002\/ajh.10300","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3,21]]}}}