{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T15:30:00Z","timestamp":1774452600689,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,6,20]],"date-time":"2003-06-20T00:00:00Z","timestamp":1056067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary effusion lymphoma (PEL) is a rare KSHV\/HHV8\u2010associated high\u2010grade non\u2010Hodgkin's lymphoma (NHL) of B\u2010cell origin, characterized by serous effusions in body cavities. Most patients are HIV\u2010infected homosexual men with severe immunosuppression and other KSHV\/HHV8\u2010associated diseases such as Kaposi's sarcoma (KS). The prognosis is poor with a median survival of less than 6 months in most cohorts. The achievement of a sustained complete remission is rare. High\u2010dose chemotherapy regimens are warranted to improve complete remission rate and survival. Seven patients with AIDS\u2010associated PEL were treated with a combined chemotherapy including high\u2010dose methotrexate followed by leucovorin rescue. In all cases, KSHV\/HHV8 sequences were detected in the effusion samples using quantitative PCR assays. Five patients had a pre\u2010existing KS, associated in three cases with multicentric Castleman's disease (MCD). Upon diagnosis, 6 patients received antiretroviral therapy, which was maintained during chemotherapy in 5 of them. At time of analysis, 3 out of 7 patients were in complete remission 18, 26, and 78 months after PEL diagnosis. Three patients died with a progressive PEL at 22, 67, and 153 days after diagnosis, and 1 patient died 9 months after PEL diagnosis with a MCD\u2010associated plasmablastic NHL. Complete remission was obtained in 3 out of 7 patients treated for AIDS\u2010associated PEL with combined chemotherapy containing high\u2010dose methotrexate. Am. J. Hematol. 73:143\u2013148, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10341","type":"journal-article","created":{"date-parts":[[2003,6,23]],"date-time":"2003-06-23T10:15:21Z","timestamp":1056363321000},"page":"143-148","source":"Crossref","is-referenced-by-count":58,"title":["Combined chemotherapy including high\u2010dose methotrexate in KSHV\/HHV8\u2010associated primary effusion lymphoma"],"prefix":"10.1002","volume":"73","author":[{"given":"Emmanuelle","family":"Boulanger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Th\u00e9r\u00e8se","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix","family":"Agbalika","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Oksenhendler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,6,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.2.645.bloodjournal882645"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/105.2.221"},{"key":"e_1_2_1_4_2","first-page":"1358","article-title":"Detection of HHV\u20108\/KSHV DNA sequences in AIDS\u2010associated extranodal lymphoid malignancies","volume":"10","author":"Otsuki T","year":"1996","journal-title":"Leukemia"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-199611010-00003"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90153-2"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199912240-00021"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200096"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199714000-00009"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.1.132-136.1999"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.2.772-775.2001"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.8.3124.bloodjournal8883124"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-125-10-199611150-00006"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02936.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002779900145"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190109058002"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2000.02478.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(200102)193:2<200::AID-PATH773>3.0.CO;2-L"},{"key":"e_1_2_1_19_2","first-page":"3487","article-title":"Effect of route of administration and effusions on methotrexate pharmacokinetics","volume":"34","author":"Wan SH","year":"1974","journal-title":"Cancer Res"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt197823168"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1999.0165"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808133390705"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199803)57:3<266::AID-AJH25>3.0.CO;2-7"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.10341","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.10341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T17:39:25Z","timestamp":1700242765000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.10341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,20]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["10.1002\/ajh.10341"],"URL":"https:\/\/doi.org\/10.1002\/ajh.10341","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,20]]}}}