{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:59:41Z","timestamp":1770821981964,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,7,18]],"date-time":"2003-07-18T00:00:00Z","timestamp":1058486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swiss Foundation for Medical-Biological Grants","award":["1087"],"award-info":[{"award-number":["1087"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Deficient nuclear segmentation and abnormal chromatin condensation define Pelger\u2010Hu\u00ebt anomaly of polymorphonuclear neutrophils. Next to the hereditary irreversible form, acquired forms both reversible and irreversible have been described. We describe three transplant patients who were all investigated for a left shift in the absence of symptoms or signs of infection and in whom acquired reversible Pelger\u2010Hu\u00ebt anomaly was discovered. The abnormal PMN phenotype was induced by mycophenolate mofetil (MMF). MMF is a necessary but not sufficient condition for the development of the anomaly. In our three patients a dose\u2013response effect was observed regarding plasma MMF concentration and severity of neutrophil dysplasia. Except for one slightly elevated value, the patients' plasma MMF levels were within the therapeutic range. None of the patients, one who was neutropenic at presentation and two who were non\u2010neutropenic, developed infectious complications. From our three cases as well as those of other authors, we identify previous graft rejection episodes as a potential predisposing factor for the development of PHA. In the first patient, drug withdrawal led to normalization of PMN morphology. In the other two patients, the left shift disappeared after dose reduction. In these latter two patients, a form of desensitization to the effect of MMF on neutro\u2010 phils was observed following re\u2010augmentation of MMF dose. Am. J. Hematol. 73:244\u2013248, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10359","type":"journal-article","created":{"date-parts":[[2003,7,21]],"date-time":"2003-07-21T10:11:54Z","timestamp":1058782314000},"page":"244-248","source":"Crossref","is-referenced-by-count":24,"title":["Acquired and reversible Pelger\u2010Hu\u00ebt anomaly of polymorphonuclear neutrophils in three transplant patients receiving mycophenolate mofetil therapy"],"prefix":"10.1002","volume":"73","author":[{"given":"Lars 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