{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T05:06:30Z","timestamp":1700283990703},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,8,25]],"date-time":"2003-08-25T00:00:00Z","timestamp":1061769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report here the case of a 44\u2010year\u2010old woman with thrombocytopenia, anemia, convulsions, hyperprolactinemia, and galactorrhea. The patient died of cardiac failure. Autopsy revealed PAS\u2010positive and von Willebrand factor\u2010positive microthrombi in the arterioles and capillaries of many organs, mainly in the heart and brain, confirming the clinical diagnosis of thrombotic thrombocytopenic purpura. In the pituitary, a prolactin\u2010producing adenoma was identified. To our knowledge, thrombotic thrombocytopenic purpura accompanied by a prolactin\u2010secreting pituitary adenoma has not yet been described. The question of whether the association between the vascular changes and the pituitary adenoma is incidental or causal cannot be answered. Further studies are required to determine whether prolactin released from the pituitary tumor in excess played a role in the formation of microthrombi causing multiple organ failure and the demise of the patient. Am. J. Hematol. 74:55\u201359, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10366","type":"journal-article","created":{"date-parts":[[2003,8,27]],"date-time":"2003-08-27T13:39:22Z","timestamp":1061991562000},"page":"55-59","source":"Crossref","is-referenced-by-count":3,"title":["Thrombotic thrombocytopenic purpura associated with a prolactin\u2010producing pituitary adenoma"],"prefix":"10.1002","volume":"74","author":[{"given":"Kalman","family":"Kovacs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Bernadette","family":"Garvey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,8,25]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1925.00120130092009"},{"key":"e_1_2_1_3_2","first-page":"43","article-title":"Acute febrile anemia and thrombocytopenic purpura with diffuse platelet thromboses of capillaries and arterioles","volume":"51","author":"Baehr G","year":"1936","journal-title":"Trans Assoc Am Phys"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199601)51:1<1::AID-AJH1>3.0.CO;2-2"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jca.10005"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)80030-5"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1996.tb01930.x"},{"key":"e_1_2_1_8_2","first-page":"148","article-title":"Thrombotic microangiopathy during pregnancy","volume":"34","author":"McCrae KR","year":"1997","journal-title":"Semin Hematol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.4065\/76.11.1154"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020528"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(02)00085-0"},{"key":"e_1_2_1_12_2","first-page":"83","article-title":"Studies on the pathophysiology of thrombotic thrombocytopenic purpura","volume":"34","author":"Moake JL","year":"1997","journal-title":"Semin Hematol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3536(98)80062-0"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811263392203"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1055\/s-0038-1646889","article-title":"von Willebrand factor multimer patterns in pregnancy\u2010induced hypertension","volume":"62","author":"Brenner B","year":"1989","journal-title":"Thromb Hemost"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009952930425"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198101153040306"},{"key":"e_1_2_1_18_2","first-page":"4","article-title":"Pathology of prolactin cell adenomas of the human pituitary","volume":"3","author":"Horvath E","year":"1986","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00005792-196603000-00003","article-title":"Thrombotic thrombocytopenic purpura: report of 16 cases and review of the literature","volume":"45","author":"Amorosi EL","year":"1996","journal-title":"Medicine"},{"key":"e_1_2_1_20_2","first-page":"161","article-title":"Fatal thrombotic thrombocytopenic purpura (TTP) presenting concurrently with metastatic multiple endocrine neoplasia (MEN) type I","volume":"10","author":"Kouides PA","year":"1996","journal-title":"Hematopathol Mol Hematol"},{"key":"e_1_2_1_21_2","first-page":"639","article-title":"Extrapituitary prolactin: Distribution, regulation, functions, and clinical aspects","volume":"17","author":"Ben\u2010Jonathan N","year":"1996","journal-title":"Endocr Rev"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.19.3.0334"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.4.1523"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1730219"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1991.tb00708.x"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1995.0033"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.10366","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.10366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T03:25:34Z","timestamp":1700277934000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.10366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8,25]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["10.1002\/ajh.10366"],"URL":"https:\/\/doi.org\/10.1002\/ajh.10366","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,8,25]]}}}