{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:48:08Z","timestamp":1773010088624,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,7,18]],"date-time":"2003-07-18T00:00:00Z","timestamp":1058486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although overt stroke is a common complication of sickle cell disease (SCD), its incidence is very low in Kuwaiti patients. On the other hand, the prevalence of silent brain infarcts, which is reported to be about 17\u201320% in American patients, has not been documented in adult Kuwaiti patients. This is a 1\u2010year study of consecutive, asymptomatic SCD patients seen in the hematology clinic of Mubarak Al\u2010Kabeer Hospital. Patients with a past history of seizure or any other neurological abnormality were excluded. The patients' charts were reviewed for frequency of hospitalizations, any documented complications, and steady\u2010state CBC. MRI was done with a 1.5\u2010Tesla unit with super\u2010conducting magnet. T1\u2010 and T2\u2010weighted sagittal and axial sections and proton\u2010density axial images were obtained in 5\u2010mm\u2010thick sections. Thirty\u2010five patients were studied, made up of 25 SS and 10 S\u03b2<jats:sup>0<\/jats:sup>Thal, aged between 17 and 44 years, with a mean age of 26.9 \u00b1 9.3 years. MRI findings consistent with infarcts were found in 7 (20.0%) patients\u20146 SS and 1 S\u03b2<jats:sup>0<\/jats:sup>thal\u2014with a mean age of 31.8 \u00b1 8.2 years, which was significantly higher (<jats:italic>P<\/jats:italic> &lt; 0.05) than the mean age of the unaffected group (25.1 \u2013 9.0 years). There were also no differences in the mean Hb, Hb F, or any other hematological parameter in the two groups. Among the affected 6 SS, 2 had co\u2010existent \u03b1\u2010thal trait. It is interesting that, while silent infarcts are prevalent in young American patients, it is in the older age group that they occur in Kuwaiti patients. Further studies are needed to investigate the factors modulating this heterogeneity. Am. J. Hematol. 73:240\u2013243, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10376","type":"journal-article","created":{"date-parts":[[2003,7,21]],"date-time":"2003-07-21T10:11:54Z","timestamp":1058782314000},"page":"240-243","source":"Crossref","is-referenced-by-count":38,"title":["Silent brain infarcts in adult Kuwaiti sickle cell disease 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