{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:42:39Z","timestamp":1778560959756,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,8,25]],"date-time":"2003-08-25T00:00:00Z","timestamp":1061769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bacterial and protozoal infections can cause thrombocytopenia and may mimic idiopathic thrombocytopenic purpura (ITP). <jats:italic>Brucella<\/jats:italic> species and <jats:italic>Toxoplasma<\/jats:italic> are among the infectious agents with protean clinical manifestations which may induce immune thrombocytopenia. In rare cases, thrombocytopenia can be severe and may result bleeding into the skin and from mucosal sites. Prompt recognition of this complication and aggressive therapy are essential, since the mortality associated with bleeding into the central nervous system is high. We report two patients with complaints of severe epistaxis and thrombocytopenia associated with brucellosis and toxoplasmosis. Thrombocytopenic purpura in these cases responded well to the high\u2010dose corticosteroid treatment with platelet recovery within 2\u20133 days. For cases with infection\u2010induced immune thrombocytopenic purpura, short\u2010term high\u2010dose corticosteroids may be applied as an urgent therapy without worsening of the clinical condition. Am. J. Hematol. 74:52\u201354, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10382","type":"journal-article","created":{"date-parts":[[2003,8,27]],"date-time":"2003-08-27T13:39:22Z","timestamp":1061991562000},"page":"52-54","source":"Crossref","is-referenced-by-count":22,"title":["Immune thrombocytopenic purpura associated with <i>Brucella<\/i> and <i>Toxoplasma<\/i> infections"],"prefix":"10.1002","volume":"74","author":[{"given":"Emel","family":"G\u00fcrkan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fikri","family":"Ba\u015flami\u015fli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birol","family":"G\u00fcven\u00e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berna","family":"Bozkurt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c7a\u011fatay","family":"\u00dcnsal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,8,25]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00918802"},{"key":"e_1_2_1_3_2","series-title":"Wintrobe's clinical hematology","author":"Levine SH","year":"1999"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197904053001404"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80720-2"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114074"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/150.3.419"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/318129"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.2000.00334.x"},{"key":"e_1_2_1_10_2","series-title":"Principles and practice of infectious diseases","author":"Beaman M","year":"1995"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.280.6230.1505-a"},{"key":"e_1_2_1_12_2","first-page":"493","article-title":"About a case of chronic autoimmune thrombocytopenic purpura associated with toxoplasmosis","volume":"59","author":"Lepileur B","year":"2001","journal-title":"Ann Biol Clin"},{"key":"e_1_2_1_13_2","first-page":"135","article-title":"Peripheral thrombopenic purpura associated with acquired toxoplasmosis","volume":"19","author":"Michez D","year":"1998","journal-title":"Rev Med Brux"},{"key":"e_1_2_1_14_2","first-page":"129","article-title":"Thrombopenic purpura and acquired toxoplasmosis","volume":"16","author":"Borderon JC","year":"1969","journal-title":"Ann Pediatr"},{"key":"e_1_2_1_15_2","first-page":"710","article-title":"Lymph node toxoplasmosis, recurrent autoimmune thrombopenia and Hodgkin's disease","volume":"141","author":"Hauteville D","year":"1990","journal-title":"Ann Med Intern"},{"key":"e_1_2_1_16_2","first-page":"63","article-title":"Hematological manifestations in brucellosis cases in Turkey","volume":"52","author":"Akdeniz H","year":"1998","journal-title":"Acta Med Okayama"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.10382","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.10382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T03:25:23Z","timestamp":1700277923000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.10382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8,25]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["10.1002\/ajh.10382"],"URL":"https:\/\/doi.org\/10.1002\/ajh.10382","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,8,25]]}}}