{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T18:07:59Z","timestamp":1758823679250},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,9,19]],"date-time":"2003-09-19T00:00:00Z","timestamp":1063929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatitis C virus (HCV) is an RNA virus in the Flaviviridae family. It displays lymphotropism in addition to hepatotropism and extrahepatic manifestations are very well known. There are many studies showing an association between HCV infection and non\u2010Hodgkin's lymphomas (NHL). In this study the evidence for HCV infection was studied in cases with NHL. To this end, anti\u2010HCV antibody and HCV\u2010RNA were screened in serum samples of cases with NHL using third\u2010generation ELISA and RT\u2010PCR. Anti\u2010HCV antibody was studied in 223 patients and was found to be positive in 18 cases (8.1%). Anti\u2010HCV antibody positivity was compared with our blood bank \/ blood donor population. There was an important increased risk of HCV infection\u2014the common odds ratio was 34.56 and corrected odds ratio was 19.07. HCV\u2010RNA was studied in 67 of 223 serum samples. HCV\u2010RNA was found to be positive in 21 of 67 samples (31.3%). When compared with clinico\u2010demographic parameters for anti\u2010HCV and HCV\u2010RNA, including age, nodal status, and grade (in evaluable cases), except age in cases with or without HCV\u2010RNA, we did not find an important correlation with HCV status and clinical findings (<jats:italic>P<\/jats:italic> = 0.155; 0.442; 0.288 for anti\u2010HCV and 0.027; 0,558; 0.126, respectively). These results suggest that HCV infection may be an important risk factor for lymphomagenesis and HCV\u2010RNA is more useful for the detection of HCV infection in these immunosuppressed cases. Simultaneous detection of anti\u2010HCV and HCV\u2010RNA will be more informative in this population. Am. J. Hematol. 74:89\u201393, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10386","type":"journal-article","created":{"date-parts":[[2003,9,22]],"date-time":"2003-09-22T10:38:08Z","timestamp":1064227088000},"page":"89-93","source":"Crossref","is-referenced-by-count":14,"title":["Anti\u2010HCV and HCV\u2010RNA prevalence and clinical correlations in cases with non\u2010Hodgkin's lymphoma"],"prefix":"10.1002","volume":"74","author":[{"given":"Semra","family":"Paydas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banu","family":"Kilic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinan","family":"Yavuz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umut","family":"Disel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kahraman","family":"Tanriverdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berksoy","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Refik","family":"Burgut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,9,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2523562"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-125-4-199608150-00017"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(92)90073-X"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199211193272104"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-7-573"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1993.tb00782.x"},{"key":"e_1_2_1_8_2","first-page":"209","article-title":"Extrahepatic manifestations of the hepatitis C virus","volume":"29","author":"Cohen P","year":"2000","journal-title":"Presse Med"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01726453"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-7-573"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90862-7"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90132-5"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1182\/blood.V84.9.3047.3047","article-title":"Low\u2010grade malignant lymphoma, hepatitis C virus infection, and mixed cryoglobulinemia","volume":"84","author":"Pozzatto G","year":"1994","journal-title":"Blood"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.12.3701.3701"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.10.4296.bloodjournal87104296"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008361311409"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00402-7"},{"key":"e_1_2_1_18_2","first-page":"24","article-title":"Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders","volume":"4","author":"Shirin H","year":"2002","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_1_19_2","first-page":"657","article-title":"Prevalence of hepatitis C infection in patients with non\u2010Hodgkin's lymphoma","volume":"9","author":"Chindamo MC","year":"2002","journal-title":"Oncol Rep"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0226"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90991-5"},{"key":"e_1_2_1_22_2","first-page":"771","article-title":"Hepatitis C virus infection in patients with lymphoproliferative disorders","volume":"92","author":"McCool MD","year":"1996","journal-title":"Br J Haematol"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.1101"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1054\/blre.2002.0194"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.32149"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02571.x"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1182\/blood.V89.8.3066","article-title":"Lack of preferential localization of tumoral mass in B\u2010cell non\u2010Hodgkin's lymphoma associated with hepatitis C virus infection","volume":"89","author":"Zignego AL","year":"1997","journal-title":"Blood"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(01)00027-3"},{"key":"e_1_2_1_29_2","first-page":"147","article-title":"Prevalence of helicobacter pylori and hepatitis C virus infections among non\u2010Hodgkin's lymphoma patients in Southern Switzerland","volume":"85","author":"Zucca E","year":"2000","journal-title":"Hematologica"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.39.112"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(200006)64:2<95::AID-AJH4>3.0.CO;2-A"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(95)00091-7"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-6-199709150-00002"},{"key":"e_1_2_1_34_2","first-page":"223","article-title":"Primary hepatic lymphoma and association of hepatitis C viral infection","volume":"88","author":"Page RD","year":"1996","journal-title":"Blood"},{"key":"e_1_2_1_35_2","first-page":"880","article-title":"Absence of hepatitis C virus infection in non\u2010Hodgkin's lymphoma","volume":"96","author":"Thalen DJ","year":"1997","journal-title":"Br J Haematol"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199609067589"},{"key":"e_1_2_1_37_2","first-page":"771","article-title":"Hepatitis C virus infection in patients with lymphoproliferative disorders","volume":"92","author":"McColl MD","year":"1996","journal-title":"Br J Haematol"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290422"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6346(98)00079-5"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00282-999-0191-7"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990118)80:2<237::AID-IJC12>3.0.CO;2-I"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690522"},{"key":"e_1_2_1_43_2","first-page":"589","article-title":"Liver involvement during HCV infection in chronic lymphoproliferative diseases","volume":"81","author":"Andriani A","year":"1996","journal-title":"Hematologica"},{"key":"e_1_2_1_44_2","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1182\/blood.V93.5.1778","article-title":"Hepatitis C virus infection in patients with overt B\u2010cell non\u2010Hodgkin's lymphoma in a French center","volume":"93","author":"Germanidis G","year":"1999","journal-title":"Blood"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.4067\/S0034-98872001000100003"},{"key":"e_1_2_1_46_2","first-page":"162","article-title":"Evaluation of hepatitis B and C virus infection with non\u2010Hodgkin's lymphoma and without liver disease","volume":"81","author":"Musolino C","year":"1996","journal-title":"Haematologica"},{"key":"e_1_2_1_47_2","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1182\/blood.V82.8.2564.2564","article-title":"Hepatitis C virus serum markers and liver disease in children with leukemia during and after chemotherapy","volume":"82","author":"Locasciulli A","year":"1993","journal-title":"Blood"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290224"},{"key":"e_1_2_1_49_2","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1182\/blood.V91.7.2433","article-title":"Somatic hypermutation, clonal delivery and preferential expression of the VH 51pl\/VL ins 325 immunoglobulin gene contribution in hepatitis C virus associated immunocytomas","volume":"91","author":"Ivanovski M","year":"1998","journal-title":"Blood"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008255830453"},{"key":"e_1_2_1_51_2","first-page":"63","article-title":"High prevalence of hepatitis C virus infection in patients with non\u2010Hodgkin's lymphoma at the onset","volume":"89","author":"Catassi C","year":"1998","journal-title":"Rec Prog Med"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199809057606"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300107"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199706)55:2<77::AID-AJH5>3.0.CO;2-#"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.10386","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.10386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T23:34:34Z","timestamp":1700264074000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.10386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9,19]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["10.1002\/ajh.10386"],"URL":"https:\/\/doi.org\/10.1002\/ajh.10386","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9,19]]}}}