{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T12:48:17Z","timestamp":1726404497758},"reference-count":6,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,9,19]],"date-time":"2003-09-19T00:00:00Z","timestamp":1063929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hydroxyurea has been extensively used in patients with sickle cell anemia and severe sickle cell\u2010hemoglobin C (SC) disease to reduce the severity of their diseases. We report here our experience with an adult patient with severe SC disease who developed symptomatic splenomegaly requiring splenectomy while being treated with hydroxyurea. This case suggests that hydroxyurea might restore some splenic function in functionally asplenic patients with sickle cell anemia or SC disease, but also raises the clinical concern that hydroxyurea may induce splenic regrowth, resulting in symptomatic splenomegaly. With the increasing use of hydroxyurea in the management of SS disease or other hemoglobinopathies, the importance of spleen monitoring must be further emphasized in these patients. Am. J. Hematol. 74:125\u2013126, 2003. \u00a9 2003 Wiley\u2010Liss Inc.<\/jats:p>","DOI":"10.1002\/ajh.10388","type":"journal-article","created":{"date-parts":[[2003,9,22]],"date-time":"2003-09-22T10:38:08Z","timestamp":1064227088000},"page":"125-126","source":"Crossref","is-referenced-by-count":8,"title":["Hydroxyurea\u2010induced splenic regrowth in an adult patient with severe hemoglobin SC disease"],"prefix":"10.1002","volume":"74","author":[{"given":"Yiwu","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thyagarajan","family":"Ananthakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph E.","family":"Eid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,9,19]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"108","volume-title":"Sickle cell disease","author":"Serjeant GR","year":"1995"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1182\/blood.V81.4.1102.bloodjournal8141102","article-title":"Bone marrow transplantation corrects the splenic reticuloendothelial dysfunction in sickle cell anemia","volume":"81","author":"Ferster A","year":"1993","journal-title":"Blood"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.d01-1974.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1182\/blood.V88.6.1951.bloodjournal8861951","article-title":"First report of reversal of organ dysfunction in sickle cell anemia by the use of hydroxyurea: splenic regeneration","volume":"88","author":"Claster S","year":"1996","journal-title":"Blood"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904013401307"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.3173132.x"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.10388","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.10388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T23:34:38Z","timestamp":1700264078000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.10388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9,19]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["10.1002\/ajh.10388"],"URL":"https:\/\/doi.org\/10.1002\/ajh.10388","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"type":"print","value":"0361-8609"},{"type":"electronic","value":"1096-8652"}],"subject":[],"published":{"date-parts":[[2003,9,19]]}}}