{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:51:48Z","timestamp":1764996708102},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,9,19]],"date-time":"2003-09-19T00:00:00Z","timestamp":1063929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The majority of follicular lymphoma and Burkitt's lymphoma are associated with reciprocal translocations involving <jats:italic>BCL2<\/jats:italic> and <jats:italic>cMYC<\/jats:italic>, respectively. Unusual reports of aggressive lymphoma presenting with both translocations have been described as well as rare cases with a third structural alteration usually involving <jats:italic>BCL6<\/jats:italic>. The patient described here presented with aggressive high\u2010grade lymphocytic leukemia, FAB subtype L2 (ALL\u2010L2), and three reciprocal translocations, t(14;18)(q32;q21), t(8;14)(q24.1;q32), and t(1;2) (q22\u201323;p13). Despite immature morphology the leukemic blasts had a mature B\u2010cell phenotype; they were positive for surface immunoglobulin heavy chains and negative for CD34, TdT, and CD10. Most reported dual t(14;18)\/t(8;14) cases have not shown sIg and were positive for CD10. Molecular genetic analyses showed the typical rearrangements of <jats:italic>BCL2<\/jats:italic> and <jats:italic>cMYC<\/jats:italic> as well as the <jats:italic>FCGR2B<\/jats:italic> gene on chromosome 1q23. The occurrence of a third oncogene rearrangement in association with the dual <jats:italic>BCL2<\/jats:italic>, cMYC translocations in ALL patients is very rare. To our knowledge, this is the first case where the third hit involves the <jats:italic>FCGR2B<\/jats:italic> locus. This report reiterates the poor prognosis associated with activation of <jats:italic>cMYC<\/jats:italic> together with elevated Bcl\u20102 expression. These data also support recent evidence that dysregulation of <jats:italic>FCGR2B<\/jats:italic> may play a role in tumor progression. Am. J. Hematol. 74:112\u2013118, 2003. \u00a9 2003 Wiley\u2010Liss Inc.<\/jats:p>","DOI":"10.1002\/ajh.10393","type":"journal-article","created":{"date-parts":[[2003,9,22]],"date-time":"2003-09-22T10:38:08Z","timestamp":1064227088000},"page":"112-118","source":"Crossref","is-referenced-by-count":11,"title":["Case of acute lymphoblastic leukemia presenting with t(14;18)\/<i>BCL2<\/i>, t(8;14)\/cMYC, and t(1;2)\/<i>FCGR2B<\/i>"],"prefix":"10.1002","volume":"74","author":[{"given":"Wenda L.","family":"Greer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine L.Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary 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