{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:32:19Z","timestamp":1791383539240,"version":"4.3.3"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,10,24]],"date-time":"2003-10-24T00:00:00Z","timestamp":1066953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sickle cell anemia in Iran is accompanied by a high level of HbF and mild clinical presentation. Here we report haplotypes of the \u03b2 gene cluster found in 81 randomly selected sickle cell patients, including 47 sickle cell anemia (SS), 17 sickle cell trait (AS), and 17 sickle\/thalassemia (S\/thal) from southwest Iran. We found all five common typical haplotypes as well as five atypical haplotypes in our patients. Except for four patients with homozygous Benin haplotype, none of the other African typical haplotypes were found in a homozygous state. Arab\u2010Indian was found to be the most prevalent haplotype in the study population. This haplotype accounted for 51.1% as the homozygous form in SS patients, where 69.1% of chromosomes in these patients had the Arab\u2010Indian haplotype. Bantu A2 was the second most prevalent haplotype among all patients. The mean %HbF in SS patients was 27.83 and in the homozygous Arab\u2010Indian haplotype it was still higher (30.40%), while in AS patients the %HbF was only 1.20. The high %G\u03b3 chain (71.81) in the Arab\u2010Indian homozygous haplotype was concomitant with the presence of an Xmn I site in both chromosomes. The presence of the Arab\u2010Indian haplotype as the predominant haplotype might be suggestive of a gene flow to\/from Saudi Arabia or India. More haplotype investigations of a normal population can clarify the high incidence of Bantu A2 haplotype in our population. Am. J. Hematol. 74:156\u2013160, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10422","type":"journal-article","created":{"date-parts":[[2003,10,27]],"date-time":"2003-10-27T03:01:00Z","timestamp":1067223660000},"page":"156-160","source":"Crossref","is-referenced-by-count":26,"title":["\u03b2\u2010Globin gene cluster haplotypes in sickle cell patients from southwest Iran"],"prefix":"10.1002","volume":"74","author":[{"given":"Z.","family":"Rahimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Karimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Haghshenass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Merat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,10,24]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.3.853"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.6.1771"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.1994.237"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb08013.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1182\/blood.V69.6.1742.1742","article-title":"Fetal hemoglobin levels and \u03b2S globin haplotypes in an Indian population with sickle cell disease","volume":"69","author":"Kulozik AE","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198504043121403"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1182\/blood.V69.4.1026.1026","article-title":"The hematologic characteristics of sickle cell anemia bearing the Bantu haplotype: the relationship between G\u03b3 and HbF level","volume":"69","author":"Nagel RL","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1182\/blood.V66.6.1463.1463","article-title":"The \u2010158 site 5\u2032 to the G\u03b3 gene and G\u03b3 expression","volume":"66","author":"Labie D","year":"1985","journal-title":"Blood"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1182\/blood.V67.5.1404.1404","article-title":"High fetal hemoglobin production in sickle cell anemia in the eastern province of Saudi Arabia is genetically determined","volume":"67","author":"Miller BA","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.14.3.168"},{"key":"e_1_2_1_12_2","first-page":"2041","volume-title":"Tietz text book of clinical chemistry","author":"Fairbanks VF","year":"1994"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/clinchem\/20.9.1111","article-title":"Differentiation of electrophoretically similar hemoglobins\u2010 such as S, D, G and P; or A2, C, E, and O by electrophoresis of the globin chains","volume":"20","author":"Schneider RG","year":"1974","journal-title":"Clin Chem"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000205859"},{"key":"e_1_2_1_15_2","first-page":"74","volume-title":"Methods in hemotology, vol. 6. 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