{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T09:56:46Z","timestamp":1783850206615,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,12,19]],"date-time":"2003-12-19T00:00:00Z","timestamp":1071792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Between March 1997 and January 2002, 18 consecutive patients (18\u201347 years) with hematological malignancies and previous proven invasive fungal infection underwent stem cell transplantation (SCT) (10 matched sibling allograft, 6 autograft, and 2 haploidentical). All patients had full myeloablative conditioning. The fungal pathogens diagnosed were <jats:italic>Aspergillus<\/jats:italic> (14), <jats:italic>Fusarium<\/jats:italic> (2), <jats:italic>Mucor<\/jats:italic> (1), <jats:italic>Exserohilum<\/jats:italic> (1), and <jats:italic>Candida<\/jats:italic> (1), involving the lungs (15), sinuses (5), and liver (1). All patients were treated pre\u2010 and during transplant with systemic antifungal therapy. Eleven out of 18 (61%) patients survived the transplant. Only 1 of 5 patients who transplanted with an active fungal infection accompanied with active leukemia survived the transplant, compared with 10\/13 (84%) survivals in patients who had no clinical and radiological signs of infection or active leukemia (<jats:italic>P<\/jats:italic> &lt; 0.025). None of the autografted patients has died, compared with 7\/12 allografted patients, of whom 5 underwent transplant with active hematological\/active fungal disease. In only 3 patients was the cause of death reactivation of previous fungal infection. Both active fungal infection and active leukemia place patients at a very high risk for procedure\u2010related mortality. Pre\u2010transplant therapy of fungal infection, aiming to achieve a clinically undetectable state of infection, followed by an antifungal treatment during transplant may allow the SCT with no fungal reactivation in selected patients. Am. J. Hematol. 75:6\u201311, 2004. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10447","type":"journal-article","created":{"date-parts":[[2003,12,22]],"date-time":"2003-12-22T08:00:47Z","timestamp":1072080047000},"page":"6-11","source":"Crossref","is-referenced-by-count":34,"title":["Stem cell transplantation post invasive fungal infection is a feasible task"],"prefix":"10.1002","volume":"75","author":[{"given":"Irit","family":"Avivi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilana","family":"Oren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuhad","family":"Haddad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob M.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eldad J.","family":"Dann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,12,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/520274"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702654"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.1.77"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840201)53:3<411::AID-CNCR2820530308>3.0.CO;2-E"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/12.6.1147"},{"issue":"5","key":"e_1_2_1_7_2","first-page":"S1","article-title":"Epidemiology of invasive fungal infections in bone marrow transplantation. 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