{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:06:53Z","timestamp":1759342013490},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,2,17]],"date-time":"2004-02-17T00:00:00Z","timestamp":1076976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thrombocytopenia often complicates the course of acute brucellosis, mainly due to bone marrow suppression or hypersplenism. Immune thrombocytopenia is also reported in brucellosis, resulting usually in massive thrombocytopenia, purpura, and spontaneous hemorrhage. We describe a case of acute brucellosis in an 85\u2010year old woman, who presented with fever, purpuric skin lesions, anemia, and rhinorrhagia. The absolute platelet count was 1000\/\u03bcL. Direct and indirect Coombs tests were positive, and a cold\u2010agglutinin was detected. The patient was diagnosed as suffering from brucellosis on the basis of a strongly positive serologic reaction and was treated with doxycycline, streptomycin, and a short course of corticosteroids, with a rapid rise in platelet number. Am. J. Hematol. 75:139\u2013141, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.10473","type":"journal-article","created":{"date-parts":[[2004,2,18]],"date-time":"2004-02-18T09:01:32Z","timestamp":1077094892000},"page":"139-141","source":"Crossref","is-referenced-by-count":26,"title":["Immune thrombocytopenia attributed to brucellosis and other mechanisms of <i>Brucella<\/i>\u2010induced thrombocytopenia"],"prefix":"10.1002","volume":"75","author":[{"given":"G.","family":"Pappas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kitsanou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Christou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Tsianos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0302.970219"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.2.283"},{"key":"e_1_2_1_4_2","first-page":"195","article-title":"Complications associated with Brucella melitensis infection","volume":"76","author":"Colmenero JD","year":"1997","journal-title":"Medicine"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/318129"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/150.3.419"},{"key":"e_1_2_1_7_2","first-page":"19","article-title":"Evaluation of the bone marrow in patients with brucellosis. 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