{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:10:27Z","timestamp":1790799027793,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,5,2]],"date-time":"2001-05-02T00:00:00Z","timestamp":988761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diagnosis of von Willebrand disease (vWD) is based on a panel of laboratory tests that measure the amount and function of von Willebrand factor (vWF). In population studies, vWF is higher in African Americans than Caucasians. Bleeding time, factor VIII activity (FVIII), vWF antigen (vWF:Ag), \u201cvWF activity\u201d ELISA (vWF:Act), ristocetin cofactor (vWF:RCof), and ristocetin\u2010induced platelet aggregation (RIPA) were measured on 123 women with menorrhagia and 123 randomly selected control women; 70 cases and 76 controls were African American. Among controls, African Americans had significantly higher levels of vWF:Ag (mean 120 vs. 102 U\/dl, <jats:italic>P<\/jats:italic> = 0.017). Among all subjects, African Americans had higher levels of vWF:Ag (mean 123 vs. 103, <jats:italic>P<\/jats:italic> = 0.001), vWF:Act (mean 101 vs. 89, <jats:italic>P<\/jats:italic> = 0.006), and FVIII (mean 118 vs. 104, <jats:italic>P<\/jats:italic> = 0.008). VWF:RCof did not differ between races (93 vs. 94 U\/dl). RIPA was reduced in African Americans (<jats:italic>P<\/jats:italic> &lt; 0.0001). In both races, women with type O blood differed significantly from those with other ABO types in vWF:Ag, vWF:Act, FVIII, and vWF:RCof. Based on criteria of two or more tests below race\u2010 and ABO\u2010specific reference ranges, 6.5% of menorrhagia cases and 0.8% of controls were classified as having vWD, or its phenocopy. Among Caucasians, no controls and 7 cases (15.6%) were classified as affected, and in African Americans, 1 control (1.3%) and 1 case (1.4%) were so classified. Racial differences in vWF further complicate the issues surrounding diagnosis of vWD. The finding of increased vWF:Ag not accompanied by increased vWF:RCof has implications for understanding the structure\u2010function relationships of vWF. Am. J. Hematol. 67:125\u2013129, 2001. Published 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.1090","type":"journal-article","created":{"date-parts":[[2002,9,10]],"date-time":"2002-09-10T23:06:08Z","timestamp":1031699168000},"page":"125-129","source":"Crossref","is-referenced-by-count":76,"title":["Population differences in von Willebrand factor levels affect the diagnosis of von Willebrand disease in African\u2010American women"],"prefix":"10.1002","volume":"67","author":[{"given":"Connie H.","family":"Miller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Dilley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Craig","family":"Hooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L.","family":"Evatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,5,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1182\/blood.V56.4.712.712","article-title":"Serial studies in von Willebrand's disease: variability versus \u201cvariants\u201d","volume":"56","author":"Abildgaard CF","year":"1980","journal-title":"Blood"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V54.1.117.117"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1182\/blood.V54.1.137.137","article-title":"Genetics of classic von Willebrand's disease. II. 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