{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T21:49:27Z","timestamp":1775339367127,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,5,29]],"date-time":"2001-05-29T00:00:00Z","timestamp":991094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"U.S. Public Health Service, National Cancer Institute, Department of Health and Human Services","award":["CA36727"],"award-info":[{"award-number":["CA36727"]}]},{"name":"Foundation San Salvatore"},{"name":"Stacey Greene family"},{"name":"Imperial Cancer Research Foundation, U.K."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anaplastic large\u2010cell lymphoma (ALCL) is a heterogeneous process that may have a T\u2010cell, B\u2010cell, or indeterminant (null) phenotype and which may or may not express the anaplastic lymphoma kinase (ALK) oncoprotein. Because the clinical significance of these variants of ALCL is unclear, we evaluated the cases of ALCL\u2010T\/null and ALCL\u2010B identified in the Non\u2010Hodgkin's Lymphoma Classification Project. We evaluated 1,378 cases of non\u2010Hodgkin's lymphoma (NHL), and a consensus diagnosis of ALCL\u2010T\/null was made in 33 patients (2.4%) with a diagnostic accuracy of 85%. Compared to 96 patients with other forms of peripheral T\u2010cell lymphoma (PTCL), those with ALCL\u2010T\/null were significantly younger, less likely to have advanced\u2010stage disease or bone marrow involvement, more likely to have a low International Prognostic Index score, and had a significantly better survival. Among those with ALCL\u2010T\/null, there were no significant differences in the clinical features or survival on the basis of ALK expression. A consensus diagnosis of ALCL\u2010B was made in 15 patients (1.1%), and the diagnostic accuracy was 67%. However, compared to 366 patients with other forms of diffuse large B\u2010cell lymphoma (DLBCL), those with ALCL\u2010B were no different with regard to clinical features or survival. We conclude that patients with ALCL\u2010T\/null have favorable prognostic features and excellent survival and should be separated from those with other forms of PTCL for prognostic and therapeutic purposes. In contrast, patients with ALCL\u2010B appear to be similar to those with other forms of DLBCL. Am. J. Hematol. 67:172\u2013178, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.1102","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T20:40:11Z","timestamp":1030308011000},"page":"172-178","source":"Crossref","is-referenced-by-count":44,"title":["Systemic anaplastic large\u2010cell lymphoma: Results from the non\u2010Hodgkin's lymphoma classification project"],"prefix":"10.1002","volume":"67","author":[{"given":"Dennis D.","family":"Weisenburger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Diebold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randy D.","family":"Gascoyne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth A.","family":"MacLennan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Konrad","family":"M\u00fcller\u2010Hermelink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharat N.","family":"Nathwani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Ullrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,5,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V66.4.848.848"},{"issue":"1","key":"e_1_2_1_3_2","first-page":"S56","article-title":"The pathologic and clinical spectrum of anaplastic large cell lymphoma and correlation with ALK gene dysregulation","volume":"111","author":"Kinney MC","year":"1999","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_4_2","volume-title":"Histopathology of non\u2010Hodgkin's lymphomas (based on the updated Kiel classification)","author":"Lennert K","year":"1990"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.12.3835"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.4.539"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1200\/JCO.1993.11.5.937","article-title":"Primary Ki\u20101 anaplastic large\u2010cell lymphoma in adults: clinical characteristics and therapeutic outcome","volume":"11","author":"Shulman LN","year":"1993","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.5.899"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.1.33"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199509054759"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.7.2905.bloodjournal8772905"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.9.3727"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1182\/blood.V86.5.1954.bloodjournal8651954","article-title":"Anaplastic large cell lymphomas expressing the novel chimeric protein p80NPM\u2010ALK: a distinct clinicopathologic entity","volume":"86","author":"Shiota M","year":"1995","journal-title":"Blood"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.4.1394"},{"key":"e_1_2_1_16_2","first-page":"343","article-title":"The monoclonal antibody ALK1 identifies a distinct morphological subtype of anaplastic large cell lymphoma associated with 2p23\/ALK rearrangements","volume":"151","author":"Pittaluga S","year":"1997","journal-title":"Am J Pathol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65629-5"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.6.2076"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199911000-00009"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.5.1483"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.11.3913"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199712000-00004"},{"key":"e_1_2_1_23_2","first-page":"3591","article-title":"CD30+ anaplastic large\u2010cell lymphoma in children: analysis of 82 patients enrolled in two consecutive studies of the French Society of Pediatric Oncology","volume":"92","author":"Brugieres L","year":"1998","journal-title":"Blood"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.8.2688"},{"key":"e_1_2_1_25_2","first-page":"2697","article-title":"ALK+ lymphoma: clinico\u2010pathological findings and outcome","volume":"93","author":"Falini B","year":"1999","journal-title":"Blood"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.11.3909"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21979"},{"key":"e_1_2_1_28_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life\u2010tables","volume":"34","author":"Cox DR","year":"1972","journal-title":"J R Stat Soc"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291402"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.12.4514"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008418727472"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1991.tb01451.x"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930415)71:8<2604::AID-CNCR2820710827>3.0.CO;2-U"},{"key":"e_1_2_1_34_2","first-page":"76","article-title":"Prognostic significance of T\u2010cell phenotype in aggressive non\u2010Hodgkin's lymphomas","volume":"92","author":"Gisselbrecht C","year":"1998","journal-title":"Blood"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.6.2296"},{"key":"e_1_2_1_36_2","first-page":"2291","article-title":"Subclassification of diffuse large B\u2010cell lymphomas according to the Kiel classification: distinction of centroblastic and immunoblastic lymphomas is a significant prognostic risk factor","volume":"89","author":"Engelhard M","year":"1997","journal-title":"Blood"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.1102","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.1102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T18:40:09Z","timestamp":1733164809000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.1102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5,29]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,7]]}},"alternative-id":["10.1002\/ajh.1102"],"URL":"https:\/\/doi.org\/10.1002\/ajh.1102","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,5,29]]}}}