{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:14:42Z","timestamp":1791234882494,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,5,29]],"date-time":"2001-05-29T00:00:00Z","timestamp":991094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a case of recurrent thromboembolic disease and chronic pulmonary hypertension in an adult patient with pyruvate kinase deficiency who underwent splenectomy as a child. Thromboembolism has been reported as a complication following splenectomy for various hereditary chronic hemolytic anemias. To our knowledge, this association has not been described in patients specifically with pyruvate kinase deficiency. Our patient presented at age 37 with recurrent pulmonary emboli, 36 years after splenectomy for severe hemolytic anemia. Work\u2010up for other hypercoagulable states was negative. The mechanism for hypercoagulability in this condition is unclear but may involve a quantitative or qualitative change in disrupted thrombogenic red blood cell membranes that would normally be removed by the spleen. Clinicians should have a high index of suspicion for thrombotic events in these patients, as early diagnosis and treatment can reduce morbidity and mortality, and chronic anticoagulation may help prevent the sequelae of repeated thromboembolic events. Am. J. Hematol. 67:197\u2013199, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.1107","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T20:40:11Z","timestamp":1030308011000},"page":"197-199","source":"Crossref","is-referenced-by-count":68,"title":["Recurrent thromboembolic disease following splenectomy for pyruvate kinase deficiency"],"prefix":"10.1002","volume":"67","author":[{"given":"Roger","family":"Chou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"DeLoughery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,5,29]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"100","article-title":"A specific erythrocyte glycolytic enzyme defect (pyruvate kinase) in three subjects with congenital non\u2010spherocytic hemolytic anemia","volume":"74","author":"Valentine WN","year":"1961","journal-title":"Trans Assoc Am Phys"},{"key":"e_1_2_1_3_2","first-page":"165","article-title":"Red cell enzymopathies of the glycolytic pathway","volume":"27","author":"Tanaka KR","year":"1990","journal-title":"Semin Hematol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-2-245"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196801112780203"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005481114220"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199801)57:1<82::AID-AJH15>3.0.CO;2-B"},{"key":"e_1_2_1_8_2","first-page":"504","article-title":"Post\u2010splenectomy thrombosis and haemolytic anaemias","volume":"97","author":"Kemahli S","year":"1997","journal-title":"Br J Haemtol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.4881033.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30281-1"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1966.tb00125.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/imj.1966.15.2.122"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199602)51:2<133::AID-AJH6>3.0.CO;2-Z"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800730832"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.1107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.1107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T13:46:03Z","timestamp":1700401563000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.1107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5,29]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,7]]}},"alternative-id":["10.1002\/ajh.1107"],"URL":"https:\/\/doi.org\/10.1002\/ajh.1107","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,5,29]]}}}