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In addition to JCV, human herpesvirus 6 (HHV\u20106) was detected in the affected brain lesions of the patient by polymerase chain reaction and by in situ hybridization. HHV\u20106, recognized as a neurotropic virus, is known to be reactivated during immunosuppression and can cause fatal complications such as encephalitis\/encephalopathy. It is likely that impaired immunity associated with lymphoma and the additional immunosuppression following cytopenia\u2010inducing chemotherapies predisposed the patient to reactivated HHV\u20106 infection. Although it remains to be clarified whether HHV\u20106 plays an important role as a co\u2010agent with JCV in causing demyelination of the brain, our observation alerts physicians to the possible association of HHV\u20106 with the pathogenesis of PML. Am. J. Hematol. 67:200\u2013205, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.1108","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T20:40:11Z","timestamp":1030308011000},"page":"200-205","source":"Crossref","is-referenced-by-count":24,"title":["Detection of human herpesvirus 6 and JC virus in progressive multifocal leukoencephalopathy complicating follicular 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