{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:01:50Z","timestamp":1759341710961},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,7,2]],"date-time":"2001-07-02T00:00:00Z","timestamp":994032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinically significant endogenous circulating heparin\u2010like anticoagulant activity has been associated with hematological malignancies, liver damage, and other pathological conditions. The source of high plasma concentrations of endogenous heparin\u2010like anticoagulants is poorly understood. We report three cases of circulating heparin\u2010like anticoagulants in three patients with hematological malignancies: CLL, multiple myeloma, and T\u2010prolymphocytic leukemia. The severity of bleeding in our patients ranged from severe epistaxis and deep\u2010site hematoma to bleeding of biopsy site and occasional ecchymosis. Am. J. Hematol. 67:256\u2013258, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.1126","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:59:21Z","timestamp":1030312761000},"page":"256-258","source":"Crossref","is-referenced-by-count":19,"title":["Report of three cases of circulating heparin\u2010like anticoagulants"],"prefix":"10.1002","volume":"67","author":[{"given":"Pilar","family":"Llamas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Outeiri\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Espinoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana B.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Rom\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 F.","family":"Tom\u00e1s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,7,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(90)90472-P"},{"key":"e_1_2_1_3_2","first-page":"672","article-title":"Acquired heparin\u2010like anticoagulant in a patient with metastatic breast carcinoma","volume":"143","author":"Rodgers GM","year":"1985","journal-title":"West J Med"},{"key":"e_1_2_1_4_2","first-page":"441","article-title":"Sindrome emorragica da anticoagulante in circolo presente dalla nascita: primo contributo della letteratura","volume":"3","author":"Crisalli M","year":"1951","journal-title":"Minerva Pediatr"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5140.38"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199808)58:4<285::AID-AJH6>3.0.CO;2-M"},{"key":"e_1_2_1_7_2","first-page":"96","article-title":"Di\u00e1tesis hemorr\u00e1gica por heparinoides circulantes en un caso de cirrosis hep\u00e1tica","volume":"89","author":"Sanchez Fayos J","year":"1963","journal-title":"Rev Clin Esp"},{"key":"e_1_2_1_8_2","first-page":"777","article-title":"Abnormal bleeding in a patient with chronic lymphocytic leukemia and acute hepatitis due to a circulating heparin\u2010like anticoagulant","volume":"85","author":"Llamas P","year":"2000","journal-title":"Haematologica"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1055\/s-0038-1651106","article-title":"Heparin\u2010like anticoagulant associated with AIDS","volume":"57","author":"De Prost D","year":"1987","journal-title":"Thromb Haemost"},{"issue":"1","key":"e_1_2_1_10_2","first-page":"376","article-title":"Evidence for the production of heparin\u2010like anticoagulant by neoplastic plasma cells (abstr)","volume":"70","author":"Kaufman PA","year":"1987","journal-title":"Blood"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.1126","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.1126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T06:38:27Z","timestamp":1696660707000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.1126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7,2]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["10.1002\/ajh.1126"],"URL":"https:\/\/doi.org\/10.1002\/ajh.1126","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7,2]]}}}