{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:20:40Z","timestamp":1773757240907,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,11,26]],"date-time":"2001-11-26T00:00:00Z","timestamp":1006732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tissue factor pathway inhibitor (TFPI) is a Kunitz\u2010type proteinase inhibitor that has a crucial role in haemostasis and is primarily synthesized in the vascular endothelium. We investigated plasma total TFPI, antiphospholipid antibodies, and some other coagulation and fibrinolytic system parameters in 30 patients with Beh\u00e7et's disease and 15 controls by the enzyme\u2010linked immunosorbent assay method. TFPI levels were significantly higher in the Beh\u00e7et's group (119 \u00b1 57.5 ng\/ml) compared with the control group (74.8 \u00b1 31.5) (<jats:italic>P<\/jats:italic> &lt; 0.009). We also noted a statistical significance in TFPI levels between patients with active disease (<jats:italic>n<\/jats:italic>:16) (139 \u00b1 55) and patients without activation (<jats:italic>n<\/jats:italic>:14) (96 \u00b1 53) (<jats:italic>P<\/jats:italic> &lt; 0.03), whereas inactive patients lacked any significance when compared with the control group (<jats:italic>P<\/jats:italic> &lt; 0.29). Other parameters disclosed no statistical significance between patients and control group except for elevated fibrinogen and plasminogen activator inhibitor\u20101 levels in the patient group (<jats:italic>P<\/jats:italic> &lt; 0.003). Increased levels of TFPI may reflect a defensive mechanism like in other diseases characterized by thrombotic tendency and represent a parameter of disease activity. Am. J. Hematol. 68:225\u2013230, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.1186","type":"journal-article","created":{"date-parts":[[2002,9,10]],"date-time":"2002-09-10T15:25:40Z","timestamp":1031671540000},"page":"225-230","source":"Crossref","is-referenced-by-count":12,"title":["Increased levels of tissue factor pathway inhibitor may reflect disease activity and play a role in thrombotic tendency in Beh\u00e7et's disease"],"prefix":"10.1002","volume":"68","author":[{"given":"Mesut","family":"Akarsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Demirkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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