{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T02:26:02Z","timestamp":1773714362574,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,11,26]],"date-time":"2001-11-26T00:00:00Z","timestamp":1006732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A patient is described who developed a peripheral T\u2010cell lymphoma (PTCL) after a 6\u2010year history of B\u2010cell chronic lymphocytic leukemia (B\u2010CLL). The progression of the T\u2010cell disease spreading to pleura and skin terminated the course of the disease. A cytogenetic analysis performed six years after the first onset of the B\u2010CLL showed the presence of two clones, one with trisomy 12 and another with inv(14)(q11q32.1) and trisomy 8. Combined immunophenotyping and fluorescence <jats:italic>in situ<\/jats:italic> hybridization demonstrated that only CD19+ cells contained a trisomy 12, whereas CD3+ cells contained a trisomy 8. Analyses of IgH and TCR rearrangements in single micromanipulated B\u2010 and T\u2010cells lacked evidence for a clonal relation between B\u2010CLL and PTCL cells. Based on our findings, we discuss the different hypotheses which might explain the development of simultaneous PTCL and B\u2010CLL. Am. J. Hematol. 68:276\u2013279, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.1190","type":"journal-article","created":{"date-parts":[[2002,9,10]],"date-time":"2002-09-10T15:25:40Z","timestamp":1031671540000},"page":"276-279","source":"Crossref","is-referenced-by-count":13,"title":["Cytogenetic and molecular characterization of a patient with simultaneous B\u2010cell chronic lymphocytic leukemia and peripheral T\u2010cell lymphoma"],"prefix":"10.1002","volume":"68","author":[{"given":"J. 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