{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:43:35Z","timestamp":1773409415038,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,4,22]],"date-time":"2004-04-22T00:00:00Z","timestamp":1082592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A total of 69 patients of B lineage ALL, 35 children (32 males, 3 females) and 34 young adults (27 males, 7 females) were studied by multiplex RT\u2010PCR to determine the relative frequency of t(9;22), t(12;21), t(1;19), and t(4;11,). Translocation (9;22) was seen in 1\/35 (2.8%) and t(1;19) in 2\/35 (5.7%) children. None of the children showed t(12;21) and t(4;11) translocations. In young adults, t(9;22) and t(1;19) were seen in 5\/34 (14.7%) and 2\/34 (5.8%) patients, respectively. None of the latter showed t(12;21) or t(4;11) translocations. Thus, there appears to be a significant under representation of the fusion transcripts for TEL\u2010AML, a good prognostic marker, in this study, unlike in the West, where it is seen in 35% of children with ALL. This, together with the generally increased leukemic burden seen in Indian patients, may explain in part, the poor treatment outcome reported. Am. J. Hematol. 76:80\u201382, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20000","type":"journal-article","created":{"date-parts":[[2004,4,22]],"date-time":"2004-04-22T18:00:59Z","timestamp":1082656859000},"page":"80-82","source":"Crossref","is-referenced-by-count":23,"title":["Paucity of TEL\u2010AML 1 translocation, by multiplex RT\u2010PCR, in B\u2010lineage acute lymphoblastic leukemia (ALL) in Indian patients"],"prefix":"10.1002","volume":"76","author":[{"given":"S.","family":"Sazawal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.I.","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.S.","family":"Arya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bhargava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(00)00025-4"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(88)90102-6"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830150105"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.2.571"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402931"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.11.4263.bloodjournal86114263"},{"key":"e_1_2_1_9_2","first-page":"991","article-title":"High incidence of TEL\/AML1 fusion resulting from a cryptic t(12;21) in childhood B\u2010lineage acute lymphoblastic leukemia in Taiwan","volume":"10","author":"Liang DC","year":"1996","journal-title":"Leukemia"},{"key":"e_1_2_1_10_2","first-page":"1463","article-title":"Detection and quantification of TEL\/AML1 fusion transcripts by polymerase chain reaction in childhood acute lymphoblastic leukemia","volume":"10","author":"Nakao M","year":"1996","journal-title":"Leukemia"},{"key":"e_1_2_1_11_2","first-page":"1319","article-title":"Comparative incidence of the rearrangements of TEL\/AML1 and ALL1 genes in pediatric precursor B acute lymphoblastic leukemias in India","volume":"13","author":"Inamdar N","year":"1998","journal-title":"Int J Oncol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10092"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91706-Z"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb03311.x"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.20000","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.20000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T21:20:56Z","timestamp":1700256056000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.20000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1002\/ajh.20000"],"URL":"https:\/\/doi.org\/10.1002\/ajh.20000","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5]]}}}