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The degree of erythrocyte and leukocyte adhesiveness\/aggregation was determined by using a simple slide test and image analysis. Patients with GD had significantly elevated concentrations of fibrinogen (328 vs. 262 mg\/dl, <jats:italic>P<\/jats:italic> &lt; 0.0001) and accelerated erythrocyte sedimentation rates (27 vs. 13 mm\/H, <jats:italic>P<\/jats:italic> &lt; 0.005). This was accompanied by a significantly enhanced degree of erythrocyte (75 vs. 85, <jats:italic>P<\/jats:italic> &lt; 0.0001) and leukocyte (3.5 vs. 1.3, <jats:italic>P<\/jats:italic> &lt; 0.002) adhesiveness\/aggregation. The low\u2010grade, smoldering, and subclinical internal inflammation in individuals with GD is accompanied by an increased degree of erythrocyte and leukocyte adhesiveness\/aggregation. These findings might have rheological consequences in terms of microcirculatory slow flow and tissue hypoxemia. Am. J. Hematol. 75:190\u2013194, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20011","type":"journal-article","created":{"date-parts":[[2004,3,25]],"date-time":"2004-03-25T19:32:44Z","timestamp":1080243164000},"page":"190-194","source":"Crossref","is-referenced-by-count":17,"title":["Rheological determinants in patients with Gaucher disease and internal 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