{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:19:21Z","timestamp":1789096761864,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,3,25]],"date-time":"2004-03-25T00:00:00Z","timestamp":1080172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Central diabetes insipidus (DI) is a rare but recognized complication of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) that is caused by leukemic infiltration to the hypothalamo\u2010neurohypophyseal system. In rare patients in whom a wide region of the hypothalamus is involved, central DI results in hypodipsic hypernatremia and dehydration. Typical DI symptoms such as polydipsia, polyuria, and marked thirst are concealed in these cases, because the hypothalamic \u201cthirst center\u201d cannot send thirst stimuli to the cerebral cortex. Herein we describe a patient with MDS developing into AML, who presented with hypodipsic hypernatremia and dehydration. A diagnosis of central DI was made on the ground of a low level of serum anti\u2010diuretic hormone (ADH) despite high serum osmolality. A magnetic resonance imaging study revealed attenuation of a physiological \u201cbright spot\u201d of the neurohypophysis. An induction course chemotherapy including regular\u2010dose cytarabine and daunorubicin produced a rapid improvement of hypernatremia. The bone marrow aspirate after two courses of chemotherapy showed complete remission. At that point, ADH release and the \u201cbright spot\u201d were recovered. In order to correctly diagnose central DI in association with hematological malignancies, we should not overlook this atypical type of DI. Am. J. Hematol. 75:213\u2013216, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20017","type":"journal-article","created":{"date-parts":[[2004,3,25]],"date-time":"2004-03-25T19:33:38Z","timestamp":1080243218000},"page":"213-216","source":"Crossref","is-referenced-by-count":11,"title":["Myelodysplastic syndrome with central diabetes insipidus manifesting hypodipsic hypernatremia and dehydration"],"prefix":"10.1002","volume":"75","author":[{"given":"Fumihiko","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuui","family":"Kishimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Handa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinuko","family":"Mitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,3,25]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1987.tb01447.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-38-5-890"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(82)90825-7"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(02)00521-6"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2002.02763.x"},{"key":"e_1_2_1_7_2","first-page":"129","article-title":"Acute myeloid leukemia with monosomy 7 accompanied by central diabetes insipidus","volume":"38","author":"Kawano C","year":"1997","journal-title":"Jpn J Clin Hematol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2001.00346.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-2977(99)00110-2"},{"key":"e_1_2_1_10_2","first-page":"356","article-title":"3q aberration and monosomy 7 in ANLL presenting with high platelet count and diabetes insipidus","volume":"79","author":"La Starza R","year":"1994","journal-title":"Haematologica"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900100313"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(92)90022-Y"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03727.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200009000-00015"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.20017","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.20017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T16:06:26Z","timestamp":1696694786000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.20017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3,25]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1002\/ajh.20017"],"URL":"https:\/\/doi.org\/10.1002\/ajh.20017","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3,25]]}}}