{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:58:42Z","timestamp":1761893922231},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,3,25]],"date-time":"2004-03-25T00:00:00Z","timestamp":1080172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clinical behavior and optimal treatment of patients presenting with skin infiltration by B\u2010cell lymphoma have not been established. To clarify this we assessed the clinical and laboratory features of 51 patients presenting with cutaneous infiltration by B\u2010cell lymphoma. Follow\u2010up data was available for 46 patients with a median age of 68 years (range 16\u201389 years) and a median follow\u2010up of 32.5 months (range 5\u2013123 months). Thirty\u2010three of 51 (65%) patients had diffuse large B\u2010cell lymphoma (DLBCL), and 15\/51 (29%) had marginal zone lymphoma (MZL). The remaining 3 patients had follicular lymphoma, CLL, and post\u2010transplant lymphoproliferative disease. Of the 33 patients with DLBCL, follow\u2010up was available in 29; 24\/29 (83%) had primary cutaneous disease, which was unifocal in 17\/24 (71%). Following treatment, 8\/24 (33%) of the primary cases relapsed. Of the 8 who relapsed, 7 had received local forms of treatment only. Follow\u2010up data was available in 14\/15 patients with MZL. 11\/14 (79%) had primary cutaneous disease, which was unifocal in 8 (73%). Following treatment, 4 of these cases relapsed (36%); all had received local therapy only. It is evident from this study that a significant proportion (\u223d20%) of patients who present with cutaneous infiltration by B\u2010cell lymphoma have systemic disease. Staging is therefore mandatory in these patients. Approximately 1\/3 patients with primary cutaneous DLBCL or MZL ultimately relapse, and relapse rates appear higher in thosepatients receiving local therapy only. Systemic or combined modality therapy may therefore be the most appropriate treatment at presentation. This should be assessed prospectively in randomized trials. Am. J. Hematol. 75:195\u2013199, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20019","type":"journal-article","created":{"date-parts":[[2004,3,25]],"date-time":"2004-03-25T19:33:16Z","timestamp":1080243196000},"page":"195-199","source":"Crossref","is-referenced-by-count":19,"title":["Cutaneous B\u2010cell lymphoma: Pathological spectrum and clinical outcome in 51 consecutive patients"],"prefix":"10.1002","volume":"75","author":[{"given":"A.","family":"Sah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.L.","family":"Barrans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.A.","family":"Parapia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.S.","family":"Jack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.G.","family":"Owen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,3,25]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70068-1"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199409049671"},{"issue":"1","key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/annonc\/8.suppl_2.S29","article-title":"Primary B\u2010cell lymphomas of the skin","volume":"8","author":"Kerl H","year":"1997","journal-title":"Ann Oncol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1997.tb01318.x"},{"key":"e_1_2_1_6_2","first-page":"354","article-title":"EORTC classification for primary cutaneous lymphomas. 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