{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:53:56Z","timestamp":1791561236957,"version":"4.3.4"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,5,20]],"date-time":"2004-05-20T00:00:00Z","timestamp":1085011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 55\u2010year\u2010old Caribbean woman with a 6\u2010year history of smoldering adult T\u2010cell leukemia\/lymphoma presented with clinical and biological symptoms of hemophagocytic syndrome. An extensive search for infectious diseases was negative. A lymph node biopsy showing large T\u2010cell lymphoma (CD4<jats:sup>\u2212<\/jats:sup>, CD25<jats:sup>+<\/jats:sup>) and findings of high LDH count and severe lymphocytosis led to the diagnosis of acute adult T\u2010cell leukemia\/lymphoma. Anti\u2010retroviral therapy combining zidovudine, lamivudine, and interferon\u2010\u03b1 was started, resulting in rapid control of both hemophagocytic syndrome and symptoms of acute adult T\u2010cell leukemia\/lymphoma. Thus, we propose that adult T\u2010cell leukemia\/lymphoma must be added to the spectrum of etiologies of hemophagocytic syndrome. Am. J. Hematol. 76:187\u2013189, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20065","type":"journal-article","created":{"date-parts":[[2004,5,20]],"date-time":"2004-05-20T22:05:44Z","timestamp":1085090744000},"page":"187-189","source":"Crossref","is-referenced-by-count":12,"title":["Hemophagocytic syndrome as a presenting sign of transformation of smoldering to acute adult T\u2010cell leukemia\/lymphoma: Efficacy of anti\u2010retroviral and interferon therapy"],"prefix":"10.1002","volume":"76","author":[{"given":"Achille","family":"Aouba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Lambotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viorel","family":"Vasiliu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Divine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Valensi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Varet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Bazarbachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Hermine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,5,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-5710(97)00584-7"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198811000-00002"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.2165\/00063030-199810060-00003"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400580"},{"key":"e_1_2_1_6_2","first-page":"1254","article-title":"Rapidly progressive fibrosis and increased CD68\u2010positive cells in the bone marrow at the terminal stage of a adult T\u2010cell leukemia accompanied by polycythemia vera","volume":"41","author":"Otawa M","year":"2000","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2000.tb02166.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199302000-00012"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.10.3619.bloodjournal86103619"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506293322604"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200195"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.20065","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.20065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T17:12:41Z","timestamp":1700154761000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.20065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,20]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1002\/ajh.20065"],"URL":"https:\/\/doi.org\/10.1002\/ajh.20065","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5,20]]}}}