{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:26:35Z","timestamp":1760297195004},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,5,20]],"date-time":"2004-05-20T00:00:00Z","timestamp":1085011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Unstable angina pectoris is associated with elevated D\u2010dimer levels. However, the operating characteristics (sensitivity, specificity, positive and negative predictive value) of the D\u2010dimer assay for the diagnosis of coronary artery disease (CAD) are unknown. Using a prospective, observational design, we collected blood from 54 patients with unstable angina pectoris at admission and assayed for ELISA D\u2010dimer levels. The sensitivity, specificity, and negative and positive prediction values for angiographically determined coronary artery disease were calculated at multiple discriminate levels. All patients underwent coronary catheterization. A statistically significant correlation was noted between ELISA D\u2010dimer levels and age, male sex, hypertension, use of \u03b2\u2010blocker, fibrinogen levels and catheterization findings. No correlation was noted between ELISA D\u2010dimer levels and degree of the coronary artery disease. Best results were provided at a discriminate level of 270 ng\/ml, with sensitivity 70%, negative predictive value 72%, and overall accuracy 67%. All discriminate levels, however, provided values too low for diagnosis. In conclusion, ELISA D\u2010dimer assay is a non\u2010sensitive, non\u2010specific test for coronary artery disease as defined by coronary catheterization. However, the assay adds information regarding the severity of disease in patients presenting with acute coronary syndrome. Am. J. Hematol. 76:121\u2013125, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20074","type":"journal-article","created":{"date-parts":[[2004,5,20]],"date-time":"2004-05-20T22:01:39Z","timestamp":1085090499000},"page":"121-125","source":"Crossref","is-referenced-by-count":9,"title":["Determinants of ELISA D\u2010dimer sensitivity for unstable angina pectoris as defined by coronary catheterization"],"prefix":"10.1002","volume":"76","author":[{"given":"David","family":"Shitrit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariella","family":"Bar\u2010Gil Shitrit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Rudensky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaqueline","family":"Sulkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Tzviony","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199201303260506"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1093\/clinchem\/44.8.1845","article-title":"Useful laboratory tests for studying thrombogenesis in acute cardiac syndromes","volume":"44","author":"Fareed J","year":"1998","journal-title":"Clin Chem"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(92)90198-K"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1985.tb07476.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.19.2517"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03510230057035"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1055\/s-0038-1653722","article-title":"Application of a novel and rapid whole blood assay for D\u2010dimer in patients with clinically suspected pulmonary embolism","volume":"73","author":"Ginsberg JS","year":"1995","journal-title":"Thromb Haemost"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(91)90867-9"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01023-8"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1055\/s-0038-1655950","article-title":"Reliability of five rapid D\u2010dimer assays compared to ELISA in the exclusion of deep venous thrombosis","volume":"77","author":"Janssen MC","year":"1997","journal-title":"Thromb Haemost"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(97)00276-4"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.5858\/1999-123-0235-DOPFDD","article-title":"Determinants of plasma fibrin D\u2010dimer sensitivity for acute pulmonary embolism as defined by pulmonary angiography","volume":"123","author":"Heit JA","year":"1999","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-199308000-00003"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(01)00221-3"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(96)00089-8"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2000.108823"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.10.2520"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198711263172201"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.21.6.1059"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.20074","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.20074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T17:11:19Z","timestamp":1700154679000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.20074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,20]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1002\/ajh.20074"],"URL":"https:\/\/doi.org\/10.1002\/ajh.20074","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5,20]]}}}