{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:10:35Z","timestamp":1791155435851,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,8,11]],"date-time":"2004-08-11T00:00:00Z","timestamp":1092182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic eosinophilic leukemia is a neoplastic condition with persistent eosinophilia as the major hematological abnormality and with the eosinophils being part of the neoplastic clone. Some cases can be recognized by traditional hematological criteria, but many can be recognized only when a clonal cytogenetic or molecular genetic abnormality is demonstrated. A range of cytogenetic and molecular genetic abnormalities has been recognized, including both those seen in other myeloid malignancies (such as trisomy 8, monosomy 7, and 20q\u2212) and those that are particularly linked to eosinophil differentiation (such as rearrangements of <jats:italic>PDGFRB<\/jats:italic>, <jats:italic>FGFR1<\/jats:italic>, and <jats:italic>PDGFRA<\/jats:italic>, the latter with formation of a <jats:italic>FIP1L1<\/jats:italic>\u2013<jats:italic>PDGFRA<\/jats:italic> fusion gene). The discovery of the <jats:italic>FIP1L1<\/jats:italic>\u2013<jats:italic>PDGFRA<\/jats:italic> fusion gene has led to the recognition that many patients who would previously have been regarded as having idiopathic hypereosinophilia actually have chronic eosinophilic leukemia. The same fusion gene has also been found in patients with hypereosinophilia and atypical bone marrow mast cells but whether this syndrome should be regarded as a variant of eosinophilic leukemia or as a variant of systemic mastocytosis remains to be established. Am. J. Hematol. 77:82\u201385, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20088","type":"journal-article","created":{"date-parts":[[2004,8,11]],"date-time":"2004-08-11T18:23:47Z","timestamp":1092248627000},"page":"82-85","source":"Crossref","is-referenced-by-count":61,"title":["Relationship between idiopathic hypereosinophilic syndrome, eosinophilic leukemia, and systemic mastocytosis"],"prefix":"10.1002","volume":"77","author":[{"given":"Barbara J.","family":"Bain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,8,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197501000-00001"},{"key":"e_1_2_1_3_2","first-page":"29","volume-title":"World Health Organization classification of tumours: pathology and genetics of tumours of haematopoietic and lymphoid tissues","author":"Bain B","year":"2001"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025217"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04458.x"},{"issue":"2","key":"e_1_2_1_6_2","first-page":"133","article-title":"The idiopathic hypereosinophilic syndrome and eosinophilic leukaemias","volume":"89","author":"Bain BJ","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910073411503"},{"key":"e_1_2_1_8_2","first-page":"291","volume-title":"World Health Organization classification of tumours: pathology and genetics of tumours of haematopoietic and lymphoid tissues","author":"Valent P","year":"2001"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000046642"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0006"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2798"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1627"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14115-3"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2274"},{"key":"e_1_2_1_15_2","first-page":"3074","article-title":"Hypereosinophilic syndrome with elevated serum tryptase is a syndrome that differs from systemic mast cell disease with eosinophilia","volume":"102","author":"Klion AD","year":"2003","journal-title":"Blood"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00108-9"},{"key":"e_1_2_1_17_2","first-page":"919a","article-title":"PKC412, inhibitor of the KIT tyrosine kinase, demonstrates efficacy in mast cell leukemia with the D816V KIT mutation","volume":"102","author":"Gotlib J","year":"2003","journal-title":"Blood"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2477"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.13.3778"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.20088","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.20088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T23:57:30Z","timestamp":1700265450000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.20088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8,11]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["10.1002\/ajh.20088"],"URL":"https:\/\/doi.org\/10.1002\/ajh.20088","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8,11]]}}}