{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:08:57Z","timestamp":1760908137795},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T00:00:00Z","timestamp":1087862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The frequency of NK\u2010cell related neoplasms was estimated among lymphoproliferative diseases diagnosed and treated in Osaka, Japan, from 1999 to 2003. The total number of registered cases was 1,400, among which 1,092 patients were diagnosed as having malignant lymphomas. There were 987 cases of non\u2010Hodgkin's lymphoma (NHL) and 105 (9.6%) of Hodgkin's lymphoma. Immunophenotypic analysis revealed that 743 patients had B\u2010cell lymphomas and 209 T\/NK\u2010cell lymphomas. Among the T\/NK\u2010cell lymphomas, 40 showed positive immunoreactivity for CD56, and thus they were judged to be NK\/T\u2010cell lymphomas. They included one blastic NK\u2010cell lymphoma and 39 NK\/T\u2010cell lymphomas. NK\/T\u2010cell lymphomas were further divided into three categories based on the main site of lesions: nasal type (23 cases), non\u2010nasal extranodal type (11 cases), and nodal type (5 cases). The positive rate of infection with the Epstein\u2010Barr virus determined by in situ hybridization was 83%, 36%, and 25% in the nasal, non\u2010nasal, and nodal type, respectively. A mosquito allergy was found in one patient with EBV\u2010positive non\u2010nasal NK\/T\u2010cell lymphoma. The present study showed that the frequency of NK\u2010cell related neoplasms among all NHLs was 4% in an ATL\u2010non\u2010endemic area of Japan. Am. J. Hematol 76:230\u2013235, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20091","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T21:03:19Z","timestamp":1087938199000},"page":"230-235","source":"Crossref","is-referenced-by-count":8,"title":["NK\u2010cell related neoplasms in Osaka, Japan"],"prefix":"10.1002","volume":"76","author":[{"given":"Hajime","family":"Miyazato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010ichi","family":"Nakatsuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiming","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Takakuwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumasa","family":"Oka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Hanamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Tatsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihisa","family":"Kanamaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyuki","family":"Aozasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,6,22]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Pathology and genetics of tumours of haematopoietic and lymphoid tissue","author":"Jaffe ES","year":"2001"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980815)83:4<806::AID-CNCR26>3.0.CO;2-V"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.12.4501"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.1.70"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.133.4.1710"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.114751"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/00000478-199601000-00012","article-title":"Report of the workshop on nasal and related extranodal angiocentric T\/natural killer cell lymphomas: definitions, differential diagnosis and epidemiology","volume":"20","author":"Jaffe ES","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008265532487"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910440112"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910520429"},{"key":"e_1_2_1_12_2","first-page":"2345","article-title":"Specific c\u2010kit mutations in sinonasal natural killer\/T\u2010cell lymphoma in China and Japan","volume":"60","author":"Hongyo T","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2001.01058.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90254-3"},{"key":"e_1_2_1_15_2","first-page":"190","article-title":"The presence and subtype of Epstein\u2010Barr virus in B\u2010 and T\u2010cell lymphomas of sino\u2010nasal region from of the Osaka and Okinawa districts of Japan","volume":"73","author":"Tomita Y","year":"1995","journal-title":"Lab Invest"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960515)77:10<2137::AID-CNCR27>3.0.CO;2-V"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199409000-00009"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200011000-00006"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1182\/blood.V81.10.2688.2688","article-title":"Nasal T\u2010cell lymphomas: a clinicopathologic entity associated with peculiar phenotype and with Epstein\u2010Barr virus","volume":"81","author":"Kanavaros P","year":"1993","journal-title":"Blood"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.114751"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199812)59:4<309::AID-AJH7>3.0.CO;2-B"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.1.54"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980801)83:3<449::AID-CNCR13>3.0.CO;2-W"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.3.666"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.20091","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.20091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:11:28Z","timestamp":1700179888000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.20091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6,22]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1002\/ajh.20091"],"URL":"https:\/\/doi.org\/10.1002\/ajh.20091","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6,22]]}}}