{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:45:39Z","timestamp":1787867139898,"version":"build-2784847793"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T00:00:00Z","timestamp":1087862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We managed two pregnancies in a woman with congenital afibrinogenemia with increasing amounts of cryoprecipitate to achieve a pre\u2010infusion fibrinogen level of 60 mg\/dL. The first pregnancy resulted in placental abruption at 36 weeks, in spite of recent cryoprecipitate infusion. Both placentas showed infarction. Post\u2010partum ovarian and renal vein thromboses complicated the second pregnancy. Mean FVIII (344%) and vWF Antigen (323%) were elevated prior to cryoprecipitate infusion, with mean post\u2010infusion levels of 367% and 363%. The clearance of fibrinogen after cryoprecipitate infusion increased during the course of pregnancy. A paradoxical prothrombotic state with embolization may play a role in the observed complications of pregnancy. Am. J. Hematol. 76:267\u2013270, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20110","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T21:03:05Z","timestamp":1087938185000},"page":"267-270","source":"Crossref","is-referenced-by-count":53,"title":["Pregnancy\u2010related thrombosis in a woman with congenital afibrinogenemia: A report of two successful pregnancies"],"prefix":"10.1002","volume":"76","author":[{"given":"H.","family":"Roqu\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Stephenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.F.","family":"Funai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Popiolek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,6,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01681.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.01993.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2000.00448.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90354-0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000291892"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1991.tb13464.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(01)00247-X"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm825"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64923-1"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9896"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1055\/s-0037-1615661","article-title":"Absence of fibrinogen in afibrinogenemia results in large but loosely packed thrombi under flow conditions","volume":"85","author":"Remjin JA","year":"2001","journal-title":"Thromb Haemost"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1055\/s-0037-1613195","article-title":"Inhibition of thrombin generation in plasma by fibrin formation (antithrombin I)","volume":"88","author":"de Bosch NB","year":"2002","journal-title":"Thromb Haemost"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(00)00492-9"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.20110","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.20110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:12:51Z","timestamp":1700179971000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.20110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6,22]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1002\/ajh.20110"],"URL":"https:\/\/doi.org\/10.1002\/ajh.20110","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6,22]]}}}