{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T22:51:53Z","timestamp":1715986313255},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,7,23]],"date-time":"2004-07-23T00:00:00Z","timestamp":1090540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Idiopathic thrombocytopenic purpura (ITP)\u2010like syndrome is a rare complication of carcinomas, and its treatment usually precedes cancer therapy in order to make further procedures safe. We describe the case of a 78\u2010year\u2010old man with a small\u2010cell lung cancer of extended stage, associated with ITP\u2010like syndrome, which proved resistant to treatment with corticosteroids and vincristine, short\u2010responsive to IV immunoglobulin, but quickly and steadily responsive to low\u2010dose interferon (ld IFN, 3 million IU, sc, twice weekly, for 8 weeks), until the patient's death, due to his primarily chemoresistant cancer. This case is, to our knowledge, the second reported ITP\u2010like syndrome in a cancer patient who had been successfully treated with ld IFN. The excellent and cost\u2010effective therapeutic index of ld IFN makes it an attractive alternative treatment in patients with this specific complication and calls for further investigation regarding its potential use as a first\u2010line treatment. Am. J. Hematol. 76:353\u2013359, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20116","type":"journal-article","created":{"date-parts":[[2004,7,23]],"date-time":"2004-07-23T17:03:33Z","timestamp":1090602213000},"page":"353-359","source":"Crossref","is-referenced-by-count":9,"title":["Successful treatment of idiopathic thrombocytopenic purpura\u2010like syndrome in a cancer patient with low\u2010dose interferon: Case report and review of the literature"],"prefix":"10.1002","volume":"76","author":[{"given":"Sophocles","family":"Tsoussis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fotini","family":"Ekonomidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erene","family":"Vourliotaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Karalis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alkiviades","family":"Dermitzakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,7,23]]},"reference":[{"issue":"3","key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0090-4295(84)90049-9","article-title":"Renal cell carcinoma and idiopathic thrombocytopenic purpura","volume":"23","author":"Klimberg I","year":"1994","journal-title":"Urology"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830340116"},{"issue":"6","key":"e_1_2_1_4_2","first-page":"430","article-title":"Recurrent ovarian carcinoma: presentation as idiopathic thrombocytopenic purpura and a splenic mass","volume":"12","author":"Tarraza HM","year":"1991","journal-title":"Eur J Gynaecol Oncol"},{"issue":"2","key":"e_1_2_1_5_2","first-page":"217","article-title":"Idiopathic thrombocytopenic purpura and monoclonal gammopathy of undermined significance accompanied by urinary bladder carcinoma","volume":"11","author":"Kaneko Y","year":"1993","journal-title":"Clin Exp Rheumatol"},{"issue":"5","key":"e_1_2_1_6_2","first-page":"424","article-title":"Lung cancer surgery in a patient with idiopathic thrombocytopenic purpura (ITP)","volume":"51","author":"Tsuchishima S","year":"1998","journal-title":"Kyobu Geka"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/28.4.270"},{"issue":"6","key":"e_1_2_1_8_2","first-page":"889","article-title":"Double lung cancer combined with idiopathic thrombocytopenic purpura. 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