{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:48:07Z","timestamp":1763016487241},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,7,23]],"date-time":"2004-07-23T00:00:00Z","timestamp":1090540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Severe thrombocytopenia is a life\u2010threatening condition. It is often associated with immune\u2010mediated platelet destruction or myeloablative chemotherapy. Infective endocarditis has been associated with thrombocytopenia, which, as in sepsis, tends to be mild and is often the result of several pathological mechanisms. We report a case of <jats:italic>Cardiobacterium hominis<\/jats:italic> endocarditis associated with very severe thrombocytopenia and bleeding in a patient who refused platelet transfusion. Platelet autoantibodies directed against glycoprotein (Gp) IIb\/IIIa and Gp Ib\/IX were detected during active infection using a glycoprotein\u2010specific assay. Successful treatment of <jats:italic>C. hominis<\/jats:italic> endocarditis was associated with loss of platelet autoantibodies and recovery of the platelet count. This report illustrates that the development of platelet autoantibodies can contribute to very severe thrombocytopenia in occasional patients with infective endocarditis. Am. J. Hematol. 76:373\u2013377, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20127","type":"journal-article","created":{"date-parts":[[2004,7,23]],"date-time":"2004-07-23T17:03:59Z","timestamp":1090602239000},"page":"373-377","source":"Crossref","is-referenced-by-count":15,"title":["<i>Cardiobacterium hominis<\/i> endocarditis associated with very severe thrombocytopenia and platelet autoantibodies"],"prefix":"10.1002","volume":"76","author":[{"given":"Donald M.","family":"Arnold","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Smaill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore E.","family":"Warkentin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Christjanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irwin","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,7,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200109000-00003"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.157.8.885"},{"issue":"5","key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1001\/jama.1977.03280050048019","article-title":"Thrombotic thrombocytopenic purpura\u2010like syndrome associated with infective endocarditis. 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