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In addition, the presence of dmin may be a mechanism for upregulated oncogene expression and is generally associated with a poor prognosis. We describe two patients who had dmin at initial presentation of AML, including the first case of M5a with <jats:italic>C\u2010MYC<\/jats:italic> amplification on dmin, and another case with <jats:italic>C\u2010MYC<\/jats:italic> amplification as the only cytogenetic finding. We review here a total of 33 cases with dmin in AML. <jats:italic>C\u2010MYC<\/jats:italic> was amplified by the dmin in 25 cases, while other putative oncogenes were amplified in the other 8. Am. J. Hematol. 77:55\u201361, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20151","type":"journal-article","created":{"date-parts":[[2004,8,11]],"date-time":"2004-08-11T18:25:23Z","timestamp":1092248723000},"page":"55-61","source":"Crossref","is-referenced-by-count":47,"title":["Double minute chromosomes in monoblastic (M5) and myeloblastic (M2) acute myeloid leukemia: Two case reports and a review of literature"],"prefix":"10.1002","volume":"77","author":[{"given":"Leno","family":"Thomas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Stamberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Gojo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron 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